ArticleNucleic acids research1989
Ventricular myosin light chain 1 is developmentally regulated and does not change in hypertension.
Article in Nucleic acids research, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- The proteomic and genomic teratogenicity elicited by valproic acid is preventable with resveratrol and α-tocopherol.PloS one · 2014Article
- Myosin-driven rescue of contractile reserve and energetics in mouse hearts bearing familial hypertrophic cardiomyopathy-associated mutant troponin T is mutation-specific.The Journal of physiology · 2012Article
- Role of essential light chain EF hand domains in calcium binding and regulation of scallop myosin.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Human cardiac myosin light chains: sequence comparisons between myosin LC1 and LC2 from normal and idiopathic dilated cardiomyopathic hearts.Molecular and cellular biochemistry · 1995Article
- Evolution of EF-hand calcium-modulated proteins. II. Domains of several subfamilies have diverse evolutionary histories.Journal of molecular evolution · 1992Review
- Identification of sequences necessary for the association of cardiac myosin subunits.The Journal of cell biology · 1991Article
- Myosin light chains and troponin C: structural and evolutionary relationships revealed by amino acid sequence comparisons.Journal of muscle research and cell motility · 1991Review
- Developmental regulation of myosin gene expression in mouse cardiac muscle.The Journal of cell biology · 1990Article
- Complete cDNA sequence of rat atrial myosin light chain 1: patterns of expression during development and with hypertension.Nucleic acids research · 1990Article
- Characterization of a rat myosin alkali light chain gene expressed in ventricular and slow twitch skeletal muscles.Nucleic acids research · 1989Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cardiac myosin heavy chain (MHC) isoform distribution has been shown to undergo changes during development, in response to hormonal stimuli, and during pathologic states like hypertension. We initiated a study of myosin light chain 1 (MLC1) expression in cardiac tissue to determine whether MLC1 undergoes changes similar to those seen for MHC. We isolated a full length cDNA for the predominant MLC1 sequence in rat hearts. This gene is expressed in ventricular tissue at much higher levels than in atrial tissue. Based on its expression pattern and sequence homology, this cDNA encodes the rat ventricular MLC1 and has been named RVMLC1. RVMLC1 is expressed at very low levels in cardiac tissue during early development and is expressed abundantly after birth and in adult hearts. The expression of RVMLC1 was found not to change in the hearts of rats with renovascular hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.