ArticleCell research2016
Long-term in vivo single-cell tracking reveals the switch of migration patterns in adult-born juxtaglomerular cells of the mouse olfactory bulb.
Article in Cell research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- MST1/Hippo promoter gene methylation predicts poor survival in patients with malignant pleural mesothelioma in the IFCT-GFPC-0701 MAPS Phase 3 trial.British journal of cancer · 2019Trial
- Multiplexed optoacoustic tracking and magnetic actuation of labeled blood cells in living mice.Science advances · 2026Article
- Glomerulus-Specific Inhomogeneity of the Basal Activity Map in the Olfactory Bulb.International journal of molecular sciences · 2026Article
- OPTRACE: Optical Imaging-Guided Transplantation and Tracking of Cells in the Mouse Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Advances in intravital imaging of adult neurogenesis in mice.Stem cell reports · 2025Review
- Functional Maturation and Experience-Dependent Plasticity in Adult-Born Olfactory Bulb Dopaminergic Neurons.The European journal of neuroscience · 2025Article
- Neuronal silence as a prosurvival factor for adult-born olfactory bulb interneurons.Stem cell reports · 2023Article
- Endogenous but not sensory-driven activity controls migration, morphogenesis and survival of adult-born juxtaglomerular neurons in the mouse olfactory bulb.Cellular and molecular life sciences : CMLS · 2023Article
- Role of serotonin in modulating the development and function of adult-born neurons in the olfactory bulb.Neural regeneration research · 2022Article
- Development of the mammalian main olfactory bulb.Development (Cambridge, England) · 2022Review
- Phenotyping clonal populations of glioma stem cell reveals a high degree of plasticity in response to changes of microenvironment.Laboratory investigation; a journal of technical methods and pathology · 2022Article
- Intrinsic Neuronal Activity during Migration Controls the Recruitment of Specific Interneuron Subtypes in the Postnatal Mouse Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Unique Functional Properties of Mature Adult-Born Neurons in the Mouse Olfactory Bulb.Stem cell reports · 2020Article
- Magnetic resonance imaging of odorant activity-dependent migration of neural precursor cells and olfactory bulb growth.NeuroImage · 2017Article
- EphA4 Regulates Neuroblast and Astrocyte Organization in a Neurogenic Niche.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Dopaminergic Neurones in the Main Olfactory Bulb: An Overview from an Electrophysiological Perspective.Frontiers in neuroanatomy · 2017Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The behavior of adult-born cells can be easily monitored in cell culture or in lower model organisms, but longitudinal observation of individual mammalian adult-born cells in their native microenvironment still proves to be a challenge. Here we have established an approach named optical cell positioning system for long-term in vivo single-cell tracking, which integrates red-green-blue cell labeling with repeated angiography. By combining this approach with in vivo two-photon imaging technique, we characterized the in vivo migration patterns of adult-born neurons in the olfactory bulb. In contrast to the traditional view of mere radial migration of adult-born cells within the bulb, we found that juxtaglomerular cells switch from radial migration to long distance lateral migration upon arrival in their destination layer. This unique long-distance lateral migration has characteristic temporal (stop-and-go) and spatial (migratory, unidirectional or multidirectional) patterns, with a clear cell age-dependent decrease in the migration speed. The active migration of adult-born cells coincides with the time period of initial fate determination and is likely to impact on the integration sites of adult-born cells, their odor responsiveness, as well as their survival rate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.