ArticleNature communications2016
Symmetric spike timing-dependent plasticity at CA3-CA3 synapses optimizes storage and recall in autoassociative networks.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed, 197 citations in OpenAlex.
- Homeostatic Plasticity Enables Stable yet Tunable Neuronal Assemblies.bioRxiv : the preprint server for biology · 2026Article
- The hippocampal CA3 area implements sequence learning of discontinuous episodes.Communications biology · 2026Article
- The Role of Plasticity in Replay: Stability Through Anti-Hebbian Rules.Hippocampus · 2026Article
- Balancing Stability and Flow in Hippocampal Networks via Inductive Bias and Learned Symmetry Breaking.bioRxiv : the preprint server for biology · 2026Article
- Developmental emergence of sparse and structured synaptic connectivity in the hippocampal CA3 memory circuit.Nature communications · 2026Article
- Relationship between N100 amplitude and T1w/T2w-ratio in the auditory cortex in schizophrenia spectrum disorders.Schizophrenia (Heidelberg, Germany) · 2026Article
- Conditions for replay of neuronal assemblies.PLoS computational biology · 2026Article
- Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability.Science (New York, N.Y.) · 2025Article
- Learning neural dynamics through instructive signals.bioRxiv : the preprint server for biology · 2025Article
- Optical Recordings of Unitary Synaptic Connections Reveal High and Random Local Connectivity between CA3 Pyramidal Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Selective inhibition in CA3: A mechanism for stable pattern completion through heterosynaptic plasticity.PLoS computational biology · 2025Article
- Impact of symmetry in local learning rules on predictive neural representations and generalization in spatial navigation.PLoS computational biology · 2025Article
- Article
- A non-Hebbian code for episodic memory.Science advances · 2025Article
- The Impact of Electrophysiological Diversity on Pattern Completion in Lithium Nonresponsive Bipolar Disorder: A Computational Modeling Approach.Brain and behavior · 2025Article
- Regulation of sharp wave-ripples by cholecystokinin-expressing interneurons and parvalbumin-expressing basket cells in the hippocampal CA3 region.Frontiers in computational neuroscience · 2025Article
- High-Performance Memristive Synapse Based on Space-Charge-Limited Conduction in LiNbONanomaterials (Basel, Switzerland) · 2024Article
- Formation and retrieval of cell assemblies in a biologically realistic spiking neural network model of area CA3 in the mouse hippocampus.Journal of computational neuroscience · 2024Article
- Intrinsic dynamics of randomly clustered networks generate place fields and preplay of novel environments.eLife · 2024Article
- Inhibitory plasticity supports replay generalization in the hippocampus.Nature neuroscience · 2024Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
CA3-CA3 recurrent excitatory synapses are thought to play a key role in memory storage and pattern completion. Whether the plasticity properties of these synapses are consistent with their proposed network functions remains unclear. Here, we examine the properties of spike timing-dependent plasticity (STDP) at CA3-CA3 synapses. Low-frequency pairing of excitatory postsynaptic potentials (EPSPs) and action potentials (APs) induces long-term potentiation (LTP), independent of temporal order. The STDP curve is symmetric and broad (half-width ∼150 ms). Consistent with these STDP induction properties, AP-EPSP sequences lead to supralinear summation of spine [Ca(2+)] transients. Furthermore, afterdepolarizations (ADPs) following APs efficiently propagate into dendrites of CA3 pyramidal neurons, and EPSPs summate with dendritic ADPs. In autoassociative network models, storage and recall are more robust with symmetric than with asymmetric STDP rules. Thus, a specialized STDP induction rule allows reliable storage and recall of information in the hippocampal CA3 network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.