Observational studyBMJ open2016
Association between fluid intake and kidney function, and survival outcomes analysis: a nationwide population-based study.
Observational study in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Impact of recurrent dehydration with mild periodic water restriction on blood pressure and renal function in male spontaneously hypertensive rats.Experimental physiology · 2026Article
- Critical Review of the Benefit from Early Pharmacological and Dietary Support for Patients with Moderate-to-Severe (Non-Terminal) Chronic Kidney Disease.Biomedicines · 2025Review
- Carbonated Beverage, Fruit Drink, and Water Consumption and Risk of Acute Stroke: the INTERSTROKE Case-Control Study.Journal of stroke · 2024Article
- Low daily water intake profile-is it a contributor to disease?Nutrition and health · 2024Review
- Analysis on fluid intake and urination behaviors among the elderly in five cities in China: a cross-sectional study.Frontiers in nutrition · 2023Article
- Association Between Water Intake and Mortality Risk-Evidence From a National Prospective Study.Frontiers in nutrition · 2022Article
- Hydration for health hypothesis: a narrative review of supporting evidence.European journal of nutrition · 2021Review
- Cross-shift change of acute kidney injury biomarkers in sugarcane farmers and cutters.Human and ecological risk assessment : HERA · 2021Article
- Unraveling the Contribution of Fluid Therapy to the Development of Augmented Renal Clearance in a Piglet Model.Frontiers in pharmacology · 2020Article
- Water intake from foods and beverages and risk of mortality from CVD: the Japan Collaborative Cohort (JACC) Study.Public health nutrition · 2018Article
- A prospective study of water intake and subsequent risk of all-cause mortality in a national cohort.The American journal of clinical nutrition · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesFluid intake, one of the most common daily activities, has not been well studied in chronic kidney disease (CKD) populations, and clinical outcomes are rarely addressed. The aim of this nationwide study is to explore the influence of daily fluid intake on cardiovascular and all-cause mortality and its association with renal function.
designObservational cohort study.
participantsIn all, 2182 participants aged more than 20 years participated in the Third National Health and Nutrition Examination Survey (1988-1994).
main outcome measuresSurvival outcomes in patients with or without CKD, using multiple variable adjusted Cox proportional hazard models.
resultsIn a longitudinal survey with a median follow-up length of 15.4 years, 1080 participants died and 473 cardiovascular deaths were recorded. For all-cause mortality in the CKD group, individuals in the highest quartile of fluid intake (≧3.576 L/day) had better survival outcomes than those in the lowest quartile of fluid intake (≤2.147 L/day) (p=0.029) after adjustment of several pertinent variables.
conclusionsAlthough the interpretation of this observational study was limited by the failure to identify the compositions of ingested fluids, adequate hydration may offer some advantages in patients with CKD. However, the underlying pathophysiological mechanisms of the responses of normal and injured kidneys to chronic changes in fluid consumption warrant further investigation.
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