Evidence map›Paper›PMID 27173807›Full record

Trial reportBMJ open2016

Findings from a pilot Randomised trial of an Asthma Internet Self-management Intervention (RAISIN).

D Morrison, S Wyke, K Saunderson, A McConnachie, K Agur, R Chaudhuri, M Thomas, N C Thomson, L Yardley, F S Mair

Registry-linked trialOpen access · goldAbstract readClinical Trial, Phase IIIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03511482 (An Open Feasibility Study to Investigate the Impact of A Digitally Delivered Asthma Service for Patients in Primary Care), which is not on this map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03511482 nawithdrawnnot on this mapstarted 2019, after this paper: background citation

An Open Feasibility Study to Investigate the Impact of A Digitally Delivered Asthma Service for Patients in Primary Care (IDEAL-001: Integrated Digitally EnhAnced Care for Long-term Conditions-001

TypeinterventionalSponsormy mhealth LtdRan2019 to 2021Enrolled0ConditionsAsthmaArmsmyAsthma Application, Lloyds Pharmacy Online Doctor
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Home telemonitoring and remote feedback between clinic visits for asthma.The Cochrane database of systematic reviews · 2016
    Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

D MorrisonGeneral Practice & Primary Care, Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.
S WykeInstitute of Health and Wellbeing/Interdisciplinary Research Professor, College of Social Sciences, University of Glasgow, Glasgow, UK.
K SaundersonGeneral Practice & Primary Care, Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.
A McConnachieInstitute of Health and Wellbeing/Interdisciplinary Research Professor, College of Social Sciences, University of Glasgow, Glasgow, UK Robertson Centre for Biostatistics, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
K AgurGeneral Practice & Primary Care, Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.
R ChaudhuriInstitute of Infection, Immunity and Inflammation, Gartnavel General Hospital, University of Glasgow, Glasgow, UK.
M ThomasPrimary Care Research, Aldermoor Health Centre, University of Southampton, Southampton, UK.
N C ThomsonInstitute of Infection, Immunity and Inflammation, Gartnavel General Hospital, University of Glasgow, Glasgow, UK.
L YardleyDepartment of Psychology, University of Southampton, Southampton, UK.
F S MairGeneral Practice & Primary Care, Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.
University of Glasgow · GBGartnavel General Hospital · GBDrug Safety Research Unit · GBUniversity of Southampton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the feasibility of a phase 3 randomised controlled trial (RCT) of a website (Living Well with Asthma) to support self-management. DESIGN AND

settingPhase 2, parallel group, RCT, participants recruited from 20 general practices across Glasgow, UK. Randomisation through automated voice response, after baseline data collection, to website access for minimum 12 weeks or usual care.

participantsAdults (age≥16 years) with physician diagnosed, symptomatic asthma (Asthma Control Questionnaire (ACQ) score ≥1). People with unstable asthma or other lung disease were excluded.

intervention'Living Well with Asthma' is a desktop/laptop compatible interactive website designed with input from asthma/ behaviour change specialists, and adults with asthma. It aims to support optimal medication management, promote use of action plans, encourage attendance at asthma reviews and increase physical activity. OUTCOME MEASURES: Primary outcomes were recruitment/retention, website use, ACQ and mini-Asthma Quality of Life Questionnaire (AQLQ). Secondary outcomes included patient activation, prescribing, adherence, spirometry, lung inflammation and health service contacts after 12 weeks. Blinding postrandomisation was not possible.

resultsRecruitment target met. 51 participants randomised (25 intervention group). Age range 16-78 years; 75% female; 28% from most deprived quintile. 45/51 (88%; 20 intervention group) followed up. 19 (76% of the intervention group) used the website, for a mean of 18 min (range 0-49). 17 went beyond the 2 'core' modules. Median number of logins was 1 (IQR 1-2, range 0-7). No significant difference in the prespecified primary efficacy measures of ACQ scores (-0.36; 95% CI -0.96 to 0.23; p=0.225), and mini-AQLQ scores (0.38; -0.13 to 0.89; p=0.136). No adverse events.

conclusionsRecruitment and retention confirmed feasibility; trends to improved outcomes suggest use of Living Well with Asthma may improve self-management in adults with asthma and merits further development followed by investigation in a phase 3 trial. TRIAL REGISTRATION NUMBER: ISRCTN78556552; Results.

Indexed as

Patient SelectionSelf CareAdolescentAdultAgedAnti-Inflammatory AgentsAsthmaBronchodilator AgentsExerciseFeasibility StudiesFemaleHumansInternetMaleMedication AdherenceMiddle AgedAnti-Inflammatory AgentsBronchodilator AgentsPrednisoloneAdherencebehaviour changecomplex interventionInternetPRIMARY CARE

Identifiers

PMID27173807
PMCPMC4874112
OpenAlexW2346557837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.