ArticleMagnetic resonance in medicine2017
Mapping of intracellular pH in the in vivo rodent heart using hyperpolarized [1-13C]pyruvate.
Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Non-invasive visualization of pH changes within the tumor-micro-environment by positron emission tomography.EJNMMI research · 2026Article
- Technologies and Strategies for Metabolic and Molecular Imaging With Hyperpolarized MRI.Journal of magnetic resonance imaging : JMRI · 2026Review
- Review of Myocardial Ischemia, Scar, and Viability Estimation with Molecular Magnetic Resonance Imaging.Biomedicines · 2024Review
- Inhalable cardiac targeting peptide modified nanomedicine prevents pressure overload heart failure in male mice.Nature communications · 2024Article
- Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation of the Hyperpolarized Ketone and Hemiketal Forms of Allyl [1-ACS sensors · 2024Article
- [HyperpolarizedRadiologie (Heidelberg, Germany) · 2022Review
- Interrelated In Vitro Mechanisms of Sibutramine-Induced Cardiotoxicity.Cardiovascular toxicology · 2021Article
- Biomedical Applications of the Dynamic Nuclear Polarization and Parahydrogen Induced Polarization Techniques for HyperpolarizedMagnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2021Review
- A multi spin echo pulse sequence with optimized excitation pulses and a 3D cone readout for hyperpolarizedMagnetic resonance in medicine · 2020Article
- Acquisition strategies for spatially resolved magnetic resonance detection of hyperpolarized nuclei.Magma (New York, N.Y.) · 2020Review
- Clinical Cardiovascular Applications of Hyperpolarized Magnetic Resonance.Cardiovascular drugs and therapy · 2020Review
- Cardiac pH-Imaging With Hyperpolarized MRI.Frontiers in cardiovascular medicine · 2020Review
- Using bidirectional chemical exchange for improved hyperpolarized [Magnetic resonance in medicine · 2019Article
- Spatiotemporal pH Heterogeneity as a Promoter of Cancer Progression and Therapeutic Resistance.Cancers · 2019Review
- Hyperpolarised magnetic resonance for in vivo real-time metabolic imaging.Heart (British Cardiac Society) · 2018Review
- Susceptibility-induced distortion correction in hyperpolarized echo planar imaging.Magnetic resonance in medicine · 2018Article
- Noninvasive Interrogation of Cancer Metabolism with HyperpolarizedJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2017Review
- The use of hyperpolarized carbon-13 magnetic resonance for molecular imaging.Advanced drug delivery reviews · 2017Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo demonstrate the feasibility of mapping intracellular pH within the in vivo rodent heart. Alterations in cardiac acid-base balance can lead to acute contractile depression and alterations in Ca
methodsSpectrally selective radiofrequency (RF) pulses were used to excite the HCO3- and CO
resultsThe intracellular pH was measured to be 7.15 ± 0.04 at baseline, and decreased to 6.90 ± 0.06 following 15 min of continuous β-adrenergic stimulation.
conclusionsVolumetric maps of intracellular pH can be obtained following an injection of hyperpolarized [1-
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.