ReviewNature reviews. Cardiology2016
Heart failure and sleep disorders.
Review in Nature reviews. Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05915364 (MAgna GraecIa Evaluation of Comorbidities in Patients With Heart Failure STUDY), which is not on this map. Cited by 87 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
MAgna GraecIa Evaluation of Comorbidities in Patients With Heart Failure STUDY (MAGIC-HF STUDY): Observational Study on Physiopathological, Diagnostic, Therapeutic, and Predictive Aspects of Heart Failure and Associated Comorbidities
Who cites it
87 citing papers in PubMed, 2 syntheses or guidelines pooled it, 155 citations in OpenAlex.
- Meta-analysis of associated factors of sleep disorders in elderly patients with coronary heart disease.Frontiers in psychiatry · 2026Pooled it
- Impact of sacubitril/valsartan on chronic heart failure patients with sleep-disordered breathing: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Effects of continuous positive airway pressure therapy on left ventricular performance in patients with severe obstructive sleep apnea.Scientific reports · 2023Trial
- The longitudinal association between the use of antihypertensive medications and 24-hour sleep in nursing homes: results from the randomized controlled COSMOS trial.BMC geriatrics · 2021Trial
- Upward Shift and Steepening of the Blood Pressure Response to Exercise in Hypertensive Subjects at High Altitude.Journal of the American Heart Association · 2018Trial
- Stage D heart failure in the United States: A study from a national database.American heart journal plus : cardiology research and practice · 2026Article
- Sleep, Neural Circulatory Control, and Cardiovascular Disease: A Mechanistic Review.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Cardiovascular Disease, Sleep-Disordered Breathing, and Artificial Intelligence: From Neutral Trials to Precision Sleep Cardiology.Reviews in cardiovascular medicine · 2026Review
- Association of sleep disturbance during breast cancer treatment and left ventricular ejection fraction decline: a prospective cohort study.Cardio-oncology (London, England) · 2026Article
- When the Heart Meets the Pillow: Building Cross-disciplinary Solutions for Sleep-disordered Breathing.Cardiac failure review · 2026Review
- Sleep Quality and Outcomes in Preclinical Heart Failure: A Prospective UK Biobank Cohort Study.The American journal of medicine · 2025Article
- Short-term effects of DAPAgliflozin on Lung fUNction, sleep apneas, and circulatinG surfactant protein B in Heart Failure with reduced ejection fraction (DAPA-LUNG-HF).International journal of molecular sciences · 2025Article
- Differential effects of sleep position and sleep stage on the severity of obstructive sleep apnea.Journal of sleep research · 2025Article
- Prevalence and Characteristics of Sleep Apnea in Patients With Heart Failure: A Single-Center Study.Cureus · 2025Article
- Dynamic evaluation of atrial fibrillation risk factors using multiple sensors of implantable cardioverter defibrillators.International journal of cardiology. Heart & vasculature · 2025Article
- Identifying links between cardiovascular disease and insomnia by modeling genes from a pleiotropic locus.Disease models & mechanisms · 2025Article
- Association between sleep disorders and subsequent heart failure.International journal of cardiology. Heart & vasculature · 2025Article
- Neurocardiology: translational advancements and potential.The Journal of physiology · 2025Review
- A deep learning-enabled smart garment for accurate and versatile monitoring of sleep conditions in daily life.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Assessment of sleep problems in patients with Kawasaki disease: a survey-based study.BMC pediatrics · 2025Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Awareness of the importance of sleep-related disorders in patients with cardiovascular diseases is growing. In particular, sleep-disordered breathing, short sleep time, and low sleep quality are frequently reported by patients with heart failure (HF). Sleep-disordered breathing, which includes obstructive sleep apnoea (OSA) and central sleep apnoea (CSA), is common in patients with HF and has been suggested to increase the morbidity and mortality in these patients. Both OSA and CSA are associated with increased sympathetic activation, vagal withdrawal, altered haemodynamic loading conditions, and hypoxaemia. Moreover, OSA is strongly associated with arterial hypertension, the most common risk factor for cardiac hypertrophy and failure. Intrathoracic pressure changes are also associated with OSA, contributing to haemodynamic alterations and potentially affecting overexpression of genes involved in ventricular remodelling. HF treatment can decrease the severity of both OSA and CSA. Indeed, furosemide and spironolactone administration, exercise training, cardiac resynchronization therapy, and eventually heart transplantation have shown a positive effect on OSA and CSA in patients with HF. At present, whether CSA should be treated and, if so, which is the optimal therapy is still debated. By contrast, more evidence is available on the beneficial effects of OSA treatment in patients with HF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.