Evidence map›Paper›PMID 27173673›Full record

ArticlePhysiological reports2016

Properties of acid-induced currents in mouse dorsal root ganglia neurons.

Zuhal Ergonul, Lei Yang, Lawrence G Palmer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Zuhal ErgonulDepartment of Physiology and Biophysics, Weill Cornell Medical College, New York, New York Department of Pediatrics, NewYork-Presbyterian/Weill Cornell Medical Center, New York, New York.
Lei YangDepartment of Physiology and Biophysics, Weill Cornell Medical College, New York, New York Department of Physiology, Harbin Medical University, Harbin, China.
Lawrence G PalmerDepartment of Physiology and Biophysics, Weill Cornell Medical College, New York, New York lgpalm@med.cornell.edu.
Cornell University · USHarbin Medical University · CN

Funding

WCMC Child Neurology Postdoctoral Training on Developmental NeurosciencesK12NS066274 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KOSOFSKY, BARRY E · 2010 to 2019
$2.8M
Control of Renal Na and K ExcretionR01DK099284 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI PALMER, LAWRENCE G, WANG, TONG WANG · 2014 to 2017
$2.3M
Defective flow-dependent tubule transport in the pathogenesis of kidney diseaseR01DK117650 · NIDDK · YALE UNIVERSITY · PI WANG, TONG WANG · 2019 to 2022
$1.5M
NIDDK NIH HHS R01 DK099284NIDDK NIH HHS R01 DK117650NINDS NIH HHS K12 NS066274
6 · The paper itself

Abstract

Acid-sensing ion channels (ASICs) are cation channels that are activated by protons (H(+)). They are expressed in neurons throughout the nervous system and may play important roles in several neurologic disorders including inflammation, cerebral ischemia, seizures, neurodegeneration, anxiety, depression, and migraine. ASICs generally produce transient currents that desensitize in response to a decrease in extracellular pH Under certain conditions, the inactivation of ASICs can be incomplete and allow them to produce sustained currents. Here, we characterize the properties of both transient and sustained acid-induced currents in cultured mouse dorsal root ganglia (DRG) neurons. At pH levels between 7.3 and 7.1 they include "window currents" through ASICs. With stronger acid signals sustained currents are maintained in the absence of extracellular Na(+) or the presence of the ASIC blockers amiloride and Psalmotoxin-1(PcTx1). These sustained responses may have several different origins in these cells, including acid-induced stimulation of inward Cl(-) currents, block of outward K(+) currents, and augmentation of inward H(+) currents, properties that distinguish these novel sustained currents from the well-characterized transient currents.

Indexed as

Acid Sensing Ion Channel BlockersAcid Sensing Ion ChannelsAmilorideAnimalsCells, CulturedGanglia, SpinalMiceNeuronsAcid Sensing Ion Channel BlockersAcid Sensing Ion ChannelsAmilorideAmilorideASICPc1Txsustained currentsZn2+

Identifiers

PMID27173673
PMCPMC4873640
OpenAlexW2388011875

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.