Trial reportClinical oral investigations2017
Comparison of ozone gas and sodium hypochlorite/chlorhexidine two-visit disinfection protocols in treating apical periodontitis: a randomized controlled clinical trial.
Trial report in Clinical oral investigations, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Effect of root canal filling techniques and materials on endodontic treatment outcomes: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Effects of ozone therapy as an adjuvant in the treatment of periodontitis: a systematic review and meta-analysis.BMC oral health · 2025Pooled it
- Outcomes of primary root canal therapy: An updated systematic review of longitudinal clinical studies published between 2003 and 2020.International endodontic journal · 2022Pooled it
- Is apical periodontitis a matter of microbial diversity or time? A scoping review.Head & face medicine · 2026Article
- The conundrum of current endodontic disinfection strategies in microbial load reduction: a scoping review.BMC oral health · 2026Article
- The use of ozone in oral health care: a narrative review of current evidence and clinical applications.Frontiers in oral health · 2026Review
- Effectiveness of Irrigation Protocols in Endodontic Therapy: An Umbrella Review.Dentistry journal · 2025Review
- Reliability of the digital functionally generated path technique for assessing occlusal interferences and adjusting CAD-CAM zirconia crowns: an in vivo study.BMC oral health · 2024Article
- Microleakage of Restorative Materials Used for Temporization of Endodontic Access Cavities.Journal of clinical medicine · 2023Article
- Ozonized Hydrogels vs. 1% Chlorhexidine Gel for the Clinical and Domiciliary Management of Peri-Implant Mucositis: A Randomized Clinical Trial.Journal of clinical medicine · 2023Article
- A comprehensive in vitro comparison of the biological and physicochemical properties of bioactive root canal sealers.Clinical oral investigations · 2022Article
- Application of Selected Nanomaterials and Ozone in Modern Clinical Dentistry.Nanomaterials (Basel, Switzerland) · 2021Review
- Proteome Analysis of Molecular Events in Oral Pathogenesis and Virus: A Review with a Particular Focus on Periodontitis.International journal of molecular sciences · 2020Review
- Influence of Root Canal Curvature on Wall Cleanliness in the Apical Third during Canal Preparation.European endodontic journal · 2017Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIn this single-blinded, prospective, randomized, controlled clinical trial, the effectiveness of an ozone gas or NaOCl/CHX disinfection protocol was compared within the root canal treatment of apical periodontitis. MATERIALS AND
methodsSixty permanent teeth were randomly allocated to one technique. The clinical/radiographic assessment criteria included clinical symptoms, periapical index (PAI), and size of the apical lesion. In both groups, the root canal was mechanically cleaned and irrigated with NaCl and EDTA. Ozone gas (32 g m
resultsThere were no significant differences between the success rates (ozone group: 96.2/95.5 % after 6/12 months; NaOCl group: 95.5/95.2 % after 6/12 months). The differences in the decreases in PAI values and apical lesion sizes were also insignificant after 6 and 12 months. The bacterial reduction showed no significant differences between groups after chemo-mechanical treatment and after inter-appointment dressing. The most commonly found bacterial genera were Streptococcus spp., Parvimonas spp. and Prevotella spp.
conclusionsThe here used ozone gas and NaOCl/CHX protocols showed no difference in bacterial reduction in the sampled areas of the root canals. CLINICAL RELEVANCE: Within the limitations of the study, ozone gas seems to be a possible alternative disinfection agent within the root canal treatment of apical periodontitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.