ArticleMetabolism: clinical and experimental2016
Hepatic autophagy contributes to the metabolic response to dietary protein restriction.
Article in Metabolism: clinical and experimental, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Increasing autophagy with fasting and diet: separating fact from fiction.Biochemical Society transactions · 2026Review
- The hallmarks of protein and amino acid restriction in aging and longevity.Cell press blue · 2026Article
- Amino acid insufficiency impairs hepatic vitamin A mobilization in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Comprehensive Metabolomic and Microbial Analysis Following Dietary Amino Acid Reduction in Mice.Metabolites · 2024Article
- Ovarian aging in humans: potential strategies for extending reproductive lifespan.GeroScience · 2023Review
- FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice.Nature communications · 2022Article
- Amino acid starvation-induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance.EMBO reports · 2022Article
- Protein Appetite at the Interface between Nutrient Sensing and Physiological Homeostasis.Nutrients · 2021Review
- Maternal malnutrition and anaemia in India: dysregulations leading to the 'thin-fat' phenotype in newborns.Journal of nutritional science · 2021Review
- Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation.Journal of hepatology · 2020Article
- Pharmacological and nutritional modulation of autophagy in a rainbow trout (Oncorhynchus mykiss) gill cell line, RTgill-W1.In vitro cellular & developmental biology. Animal · 2020Article
- FGF21 and the Physiological Regulation of Macronutrient Preference.Endocrinology · 2020Review
- FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism.Cell reports · 2019Article
- Regulation of metabolic health by essential dietary amino acids.Mechanisms of ageing and development · 2019Review
- Periodized low protein-high carbohydrate diet confers potent, but transient, metabolic improvements.Molecular metabolism · 2018Article
- Homeostatic sensing of dietary protein restriction: A case for FGF21.Frontiers in neuroendocrinology · 2018Review
- Animal Models for the Study of the Relationships between Diet and Obesity: A Focus on Dietary Protein and Estrogen Deficiency.Frontiers in nutrition · 2017Review
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Authors and funding
9 authors at 1 institution in 1 country.
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Abstract
Autophagy is an essential cellular response which acts to release stored cellular substrates during nutrient restriction, and particularly plays a key role in the cellular response to amino acid restriction. However, there has been limited work testing whether the induction of autophagy is required for adaptive metabolic responses to dietary protein restriction in the whole animal. Here, we found that moderate dietary protein restriction led to a series of metabolic changes in rats, including increases in food intake and energy expenditure, the downregulation of hepatic fatty acid synthesis gene expression and reduced markers of hepatic mitochondrial number. Importantly, these effects were also associated with an induction of hepatic autophagy. To determine if the induction of autophagy contributes to these metabolic effects, we tested the metabolic response to dietary protein restriction in BCL2-AAA mice, which bear a genetic mutation that impairs autophagy induction. Interestingly, BCL2-AAA mice exhibit exaggerated responses in terms of both food intake and energy expenditure, whereas the effects of protein restriction on hepatic metabolism were significantly blunted. These data demonstrate that restriction of dietary protein is sufficient to trigger hepatic autophagy, and that disruption of autophagy significantly alters both hepatic and whole animal metabolic response to dietary protein restriction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.