Evidence map›Paper›PMID 27173384›Full record

ReviewJournal of neural transmission (Vienna, Austria : 1996)2016

Transcranial direct current stimulation in children and adolescents: a comprehensive review.

Ulrich Palm, Felix M Segmiller, Ann Natascha Epple, Franz-Joseph Freisleder, Nikolaos Koutsouleris, Gerd Schulte-Körne, Frank Padberg

4 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Journal of neural transmission (Vienna, Austria : 1996), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 48 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 5 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04328545 nacompletednot on this mapstarted 2017, after this paper: background citation

Transcranial Direct Current Stimulation Effect on Pain Threshold and Working Memory in Healthy Adolescents, Young Adults and Elderly: a Randomized , Cross-over, Single Blind Trial

TypeinterventionalSponsorHospital de Clinicas de Porto AlegreRan2017 to 2020Enrolled30ConditionsTranscranial Direct Current Stimulation, Working Memory, PainArmsAnodal tDCS on DLPFC, Anodal tDCS on M1, Sham tDCS
NCT04780152 phase2 / phase3unknown statusnot on this mapstarted 2021, after this paper: background citation

Assessment of Efficacy and Safety of Anodal Transcranial Direct Current Stimulation (TDCS) in Pediatric and Teenage Patients With Major Depressive Disorder During COVID-19 Pandemics

TypeinterventionalSponsorEl Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco SuarezRan2021 to 2022Enrolled172ConditionsMajor Depressive DisorderArmsTranscranial Direct Current Stimulation, Placebo-simulation of transcranial direct current stimulation, Fluoxetine Tablets
NCT05929274 nawithdrawnnot on this mapstarted 2024, after this paper: background citation

Safety and Efficacy of Transcranial Direct Current Stimulation in Pediatric Disorders of Consciousness

TypeinterventionalSponsorGiovanna CristellaRan2024 to 2028Enrolled0ConditionsDisorder of ConsciousnessArmstDCS, sham tDCS
NCT06368726 phase1enrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Results of the Application of 80 Sessions of tDCS for 12 Months in Children Between 6 and 11 Years Old With Autism Spectrum Disorder With Rare Diseases, Genetic Problems or PANDAS

TypeinterventionalSponsorSpanish Foundation for Neurometrics DevelopmentRan2024 to 2026Enrolled180ConditionsAttention, Visual Perceptual Weakness, Social Behavior, Fluency DisorderArmstDCS or Transcranial Direct Current Stimulation, Risperidone
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 5 syntheses or guidelines pooled it, 99 citations in OpenAlex.

  1. Pooled it
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  6. Safety and feasibility of transcranial direct current stimulation stratified by corticospinal organization in children with hemiparesis.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2023
    Trial
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  20. Non-invasive brain stimulation and neuroenhancement.Clinical neurophysiology practice · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ulrich PalmDepartment of Psychiatry and Psychotherapy, Klinikum der Universität München, Nußbaumstr. 7, 80336, Munich, Germany. ulrich.palm@med.uni-muenchen.de.
Felix M SegmillerDepartment of Psychiatry and Psychotherapy, Klinikum der Universität München, Nußbaumstr. 7, 80336, Munich, Germany.
Ann Natascha EppleKBO Heckscher-Klinikum, Munich, Germany.
Franz-Joseph FreislederKBO Heckscher-Klinikum, Munich, Germany.
Nikolaos KoutsoulerisDepartment of Psychiatry and Psychotherapy, Klinikum der Universität München, Nußbaumstr. 7, 80336, Munich, Germany.
Gerd Schulte-KörneDepartment of Childhood and Adolescent Psychiatry, Klinikum der Universität München, Munich, Germany.
Frank PadbergDepartment of Psychiatry and Psychotherapy, Klinikum der Universität München, Nußbaumstr. 7, 80336, Munich, Germany.
LMU Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation method that has shown promising results in various neuropsychiatric disorders in adults. This review addresses the therapeutic use of tDCS in children and adolescents including safety, ethical, and legal considerations. There are several studies addressing the dosage of tDCS in children and adolescents by computational modeling of electric fields in the pediatric brain. Results suggest halving the amperage used in adults to obtain the same peak electric fields, however, there are some studies reporting on the safe application of tDCS with standard adult parameters in children (2 mA; 20-30 min). There are several randomized placebo controlled trials suggesting beneficial effects of tDCS for the treatment of cerebral palsy. For dystonia there are mixed data. Some studies suggest efficacy of tDCS for the treatment of refractory epilepsy, and for the improvement of attention deficit/hyperactivity disorder and autism. Interestingly, there is a lack of data for the treatment of childhood and adolescent psychiatric disorders, i.e., childhood onset schizophrenia and affective disorders. Overall, tDCS seems to be safe in pediatric population. More studies are needed to confirm the preliminary encouraging results; however, ethical deliberation has to be weighed carefully for every single case.

Indexed as

AdolescentBrainChildComputer SimulationHumansNeurodevelopmental DisordersRandomized Controlled Trials as TopicTranscranial Direct Current StimulationADHDCerebral palsyDevelopmental disorderEpilepsyEthicsPsychiatric disorder

Identifiers

PMID27173384
OpenAlexW2382015271

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.