ArticleJournal of neural transmission (Vienna, Austria : 1996)2016
Prefrontal cortical thinning in HIV infection is associated with impaired striatal functioning.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Different roles of frontal versus striatal atrophy in HIV-associated neurocognitive disorders.Human brain mapping · 2019Pooled it
- Cross-sectional observational study evaluating social brain health in HIV using a research domain criteria-based approach: a protocol.BMJ open · 2026Article
- Multimodal MRI Radiomics and Machine Learning Identify Node-Level Structural and Functional Alterations in HIV-Associated Asymptomatic Neurocognitive Impairment.Neuropsychiatric disease and treatment · 2026Article
- Cortical folding pattern of asymptomatic HIV-associated neurocognitive disorders.BMC medical imaging · 2025Article
- Characteristics of cortical thickness in treated HIV-infected individuals with and without cognitive impairment.European journal of medical research · 2025Article
- Assessment of Brain Volume and Cortical Thickness in People with HIV and Major Depressive Disorder.Current HIV research · 2025Article
- Imaging of Brain Structural and Functional Effects in People With Human Immunodeficiency Virus.The Journal of infectious diseases · 2023Review
- Effects of Human Immunodeficiency Virus Infection and Former Cocaine Dependence on Neuroanatomical Measures and Neurocognitive Performance.Neuroscience · 2022Article
- Differential Effects of AIDS and Chronic Human Immunodeficiency Virus Infection on Gray Matter Volume.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- HIV-1 Tat promotes age-related cognitive, anxiety-like, and antinociceptive impairments in female mice that are moderated by aging and endocrine status.GeroScience · 2021Article
- Comorbid HIV infection and alcohol use disorders: Converging glutamatergic and dopaminergic mechanisms underlying neurocognitive dysfunction.Brain research · 2019Review
- Dopamine increases HIV entry into macrophages by increasing calcium release via an alternative signaling pathway.Brain, behavior, and immunity · 2019Article
- Double dissociation of HIV and substance use disorder effects on neurocognitive tasks dependent on striatal integrity.AIDS (London, England) · 2019Observational
- HIV infection and age effects on striatal structure are additive.Journal of neurovirology · 2019Article
- The role of catecholamines in HIV neuropathogenesis.Brain research · 2019Review
- Article
- Effects of HIV Infection, methamphetamine dependence and age on cortical thickness, area and volume.NeuroImage. Clinical · 2018Article
- The Aging Brain With HIV Infection: Effects of Alcoholism or Hepatitis C Comorbidity.Frontiers in aging neuroscience · 2018Review
- Retrosplenial cortical thinning as a possible major contributor for cognitive impairment in HIV patients.European radiology · 2017Article
- Regionally Specific Brain Volumetric and Cortical Thickness Changes in HIV-Infected Patients in the HAART Era.Journal of acquired immune deficiency syndromes (1999) · 2017Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While cortical thinning has been associated with HIV infection, it is unclear whether this reflects a direct effect of the virus, whether it is related to disruption of subcortical function or whether it is better explained by epiphenomena, such as drug abuse or comorbid medical conditions. The present study investigated the relationship between cortical thickness and subcortical function in HIV+ patients. Specifically, we examined the relationship between prefrontal cortical thickness and striatal function. Twenty-three largely treatment naïve, non-substance abusing HIV+ participants and 19 healthy controls matched for age, gender, and educational status were included. Cortical morphometry was performed using FreeSurfer software analysis. Striatal function was measured during an fMRI stop-signal anticipation task known to engage the striatum. Any cortical regions showing significant thinning were entered as dependent variables into a single linear regression model which included subcortical function, age, CD4 count, and a measure of global cognitive performance as independent predictors. The only cortical region that was significantly reduced after correction for multiple comparisons was the right superior frontal gyrus. Striatal activity was found to independently predict superior frontal gyral cortical thickness. While cortical thinning in HIV infection is likely multifactorial, viral induced subcortical dysfunction appears to play a role.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.