ReviewTrends in neurosciences2016
Signals from the Fourth Dimension Regulate Drug Relapse.
Review in Trends in neurosciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed.
- Cannabidiol Attenuates Heroin Seeking in Male Rats Associated With Normalization of Discrete Neurobiological Signatures Within the Nucleus Accumbens With Subregional Specificity.Biological psychiatry · 2026Article
- Cue-induced Magnetic Resonance Spectroscopy of Glutamate in Addiction Research: Current Evidence, Pros, and Cons.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Review
- Characterizing Microglial Morphology: Methodological Advances in Confocal Imaging and Analysis.Cells · 2025Article
- Adaptations in glutathione-based redox protein signaling pathways and alcohol drinking across species.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024Article
- Perineuronal Nets in the Rat Medial Prefrontal Cortex Alter Hippocampal-Prefrontal Oscillations and Reshape Cocaine Self-Administration Memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Transcriptional Dysregulation of Cholesterol Synthesis Underlies Hyposensitivity to GABA in the Ventral Tegmental Area During Acute Alcohol Withdrawal.Biological psychiatry · 2024Article
- Cross-species epigenetic regulation of nucleus accumbens KCNN3 transcripts by excessive ethanol drinking.Translational psychiatry · 2023Article
- Adaptor protein complex 2 in the orbitofrontal cortex predicts alcohol use disorder.Molecular psychiatry · 2023Article
- Intrusive thinking: Circuit and synaptic mechanisms of a transdiagnostic psychiatric symptom.Neuroscience and biobehavioral reviews · 2023Review
- Cannabinoid use is enhanced by stress and changes conditioned stress responses.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Addiction-induced plasticity in underlying neural circuits.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Extrasynaptic therapeutic targets in substance use and stress disorders.Trends in pharmacological sciences · 2022Review
- A mechanistic overview of approaches for the treatment of psychostimulant dependence.Frontiers in pharmacology · 2022Review
- Chronic intermittent ethanol during adolescence and adulthood alters dendritic spines in the primary motor and visual cortex in rats.Alcohol (Fayetteville, N.Y.) · 2021Article
- Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction.Molecular psychiatry · 2021Article
- Drug addiction: from bench to bedside.Translational psychiatry · 2021Review
- Differential regulation of alcohol consumption and reward by the transcriptional cofactor LMO4.Molecular psychiatry · 2021Article
- Heroin Seeking and Extinction From Seeking Activate Matrix Metalloproteinases at Synapses on Distinct Subpopulations of Accumbens Cells.Biological psychiatry · 2021Article
- Effects of ceftriaxone on ethanol drinking and GLT-1 expression in ethanol dependence and relapse drinking.Alcohol (Fayetteville, N.Y.) · 2021Article
- Oxytocin and Addiction: Potential Glutamatergic Mechanisms.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Despite the enormous societal burden of alcohol and drug addiction and abundant research describing drug-induced maladaptive synaptic plasticity, there are few effective strategies for treating substance use disorders. Recent awareness that synaptic plasticity involves astroglia and the extracellular matrix is revealing new possibilities for understanding and treating addiction. We first review constitutive corticostriatal adaptations that are elicited by and shared between all abused drugs from the perspective of tetrapartite synapses, and integrate recent discoveries regarding cell type-specificity in striatal neurons. Next, we describe recent discoveries that drug-seeking is associated with transient synaptic plasticity that requires all four synaptic elements and is shared across drug classes. Finally, we prognosticate how considering tetrapartite synapses can provide new treatment strategies for addiction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.