ArticleSurgery today2016
The effects of bevacizumab on intestinal anastomotic healing in rabbits.
Article in Surgery today, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Neoadjuvant camrelizumab and apatinib combined with chemotherapy versus chemotherapy alone for locally advanced gastric cancer: a multicenter randomized phase 2 trial.Nature communications · 2024Trial
- Risk stratification of residual abscess after surgical treatment for gastroduodenal perforation.Annals of gastroenterological surgery · 2025Article
- Shenhuang plaster enhances intestinal anastomotic healing in rabbits through activation of the TGF-β and Hippo/YAP signaling pathways.Journal of applied biomedicine · 2023Article
- The Science of Anastomotic Healing.Seminars in colon & rectal surgery · 2022Article
- Bevacizumab increases the risk of anastomosis site leakage in metastatic colorectal cancer.Frontiers in oncology · 2022Article
- Bevacizumab-associated intestinal perforation and perioperative complications in patients receiving bevacizumab.Annals of gastroenterological surgery · 2020Article
- Impact of RAS/BRAF mutation status in locally advanced rectal cancer treated with preoperative chemotherapy.International journal of clinical oncology · 2018Article
- Late anastomotic breakdown with bevacizumab in colorectal cancers, a case-based review.Irish journal of medical science · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposesThe aim of this study was to investigate the effects of the preoperative administration of BV on the healing process of intestinal anastomosis in a rabbit model.
methodsTwenty male white rabbits were randomly divided into two groups. The control group received saline 1 week before surgery, and the BV group received intravenous BV 1 week before surgery. Each rabbit underwent an enteroenterostomy and a colocolostomy. On postoperative day 7, the bursting pressures of the anastomoses, CD31 and α-smooth muscle actin (α-SMA) staining by immunohistochemistry, the gene expression of α-SMA, and collagen deposition using Picrosirius Red at the site of anastomosis were evaluated.
resultsThe bursting pressure of small bowel anastomoses was significantly lower in the BV group than in the control group (control 184 ± 10 mmHg vs. BV 140 ± 9 mmHg; p = 0.004). The microvessel counts in the anastomotic tissue were significantly lower in the BV group than in the control group in both the small bowel (p = 0.023) and colon (p = 0.008). The expression of α-SMA, and the degree of collagen deposition decreased in the anastomotic tissue in the BV group compared with the control group.
conclusionThe preoperative use of BV may therefore negatively affect the rigidity of intestinal anastomosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.