Evidence map›Paper›PMID 27172639›Full record

ArticleThe Journal of reproductive medicine

Endometrial Effects of Prolonged Therapy with the Selective Progesterone Receptor Modulator Ulipristal Acetate: A Case Report.

Gary Levy, John Elkas, Alicia Y Armstrong, Lynnette K Nieman

Open access · greenAbstract readCase Reports
In one paragraph

Article in The Journal of reproductive medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Cardiac benign metastatic leiomyoma- a comprehensive review.Cardio-oncology (London, England) · 2025
    Review
  2. Article
  3. Article
  4. Review
  5. Update on medical treatment for Cushing's disease.Clinical diabetes and endocrinology · 2016
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gary Levy
John Elkas
Alicia Y Armstrong
Lynnette K Nieman

Funding

Steroid Hormone Action In Female ReproductionZIADK075118 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI NIEMAN, LYNNETTE · 2016 to 2021
$126k
Endometrial PhysiologyZIADK075123 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI NIEMAN, LYNNETTE · 2016 to 2017
$33k
Intramural NIH HHS Z99 DK999999
6 · The paper itself

Abstract

backgroundProlonged exposure to a selective progesterone receptor modulator (ulipristal acetate) in a patient with benign metastasizing leiomyoma did not result in endometrial hyperplasia or neoplasia. CASE: A woman with history of benign metastasizing leiomyoma underwent medical treatment for 5 years with ulipristal acetate. Endometrial biopsies were performed at established intervals to monitor for intraepithelial neoplasia or progesterone receptor modulator-associated endometrial changes (PAECs). The patient tolerated UPA therapy well; there was no evidence of hyperplasia or proliferative changes associated with progesterone-associated endometrial changes.

conclusionIn this case prolonged exposure to ulipristal acetate did not result in premalignant or malignant endometrial pathology.

Indexed as

AdultBiopsyCarcinoma in SituEndometrial HyperplasiaEndometriumFemaleHumansLeiomyomaNeoplasm MetastasisNorpregnadienesPrecancerous ConditionsReceptors, ProgesteroneUterine NeoplasmsNorpregnadienesReceptors, Progesteroneulipristal acetate

Identifiers

PMID27172639
PMCPMC9552277
OpenAlexW2416590415

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.