Evidence map›Paper›PMID 27172609›Full record

ArticleG3 (Bethesda, Md.)2016

MEC-10 and MEC-19 Reduce the Neurotoxicity of the MEC-4(d) DEG/ENaC Channel in Caenorhabditis elegans.

Yushu Chen, Shashank Bharill, Robert O'Hagan, Ehud Y Isacoff, Martin Chalfie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in G3 (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. HowGenetics · 2019
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Yushu ChenDepartment of Biological Sciences, Columbia University, New York, New York 10027.
Shashank BharillDepartment of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720.
Robert O'HaganDepartment of Genetics, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854.
Ehud Y IsacoffDepartment of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720.
Martin ChalfieDepartment of Biological Sciences, Columbia University, New York, New York 10027 mc21@columbia.edu.
Columbia University · USUniversity of California, Berkeley · USRutgers, The State University of New Jersey · US

Funding

GENETIC ANALYSIS OF NEMATODE CELL DIFFERENTIATIONR01GM030997 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CHALFIE, MARTIN · 1985 to 2017
$7.1M
GENETIC ANALYSIS OF NEMATODE CELL DIFFERENTIATIONR37GM030997 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CHALFIE, MARTIN · 1999 to 2009
$6.6M
STRUCTURAL REARRANGEMENTS IN CHANNEL GATINGR01NS035549 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD · 1996 to 2013
$4.1M
Voltage Gating MechanismsR01GM117051 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD · 2016 to 2019
$1.3M
NIGMS NIH HHS R01 GM030997NIGMS NIH HHS R01 GM117051NIGMS NIH HHS R37 GM030997NINDS NIH HHS R01 NS035549
6 · The paper itself

Abstract

The Caenorhabditis elegans DEG/ENaC proteins MEC-4 and MEC-10 transduce gentle touch in the six touch receptor neurons . Gain-of-function mutations of mec-4 and mec-4(d) result in a hyperactive channel and neurodegeneration in vivo Loss of MEC-6, a putative DEG/ENaC-specific chaperone, and of the similar protein POML-1 suppresses the neurodegeneration caused by a mec-4(d) mutation. We find that mutation of two genes, mec-10 and a new gene mec-19 (previously named C49G9.1), prevents this action of POML-1, allowing the touch receptor neurons to die in poml-1 mec-4(d) animals. The proteins encoded by these genes normally inhibit mec-4(d) neurotoxicity through different mechanisms. MEC-10, a subunit of the mechanosensory transduction channel with MEC-4, inhibits MEC-4(d) activity without affecting MEC-4 expression. In contrast, MEC-19, a membrane protein specific to nematodes, inhibits MEC-4(d) activity and reduces MEC-4 surface expression.

Indexed as

Amino Acid SequenceAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsCell DeathEpithelial Sodium ChannelsGene Expression RegulationMembrane ProteinsMutationOocytesCaenorhabditis elegans ProteinsDeg-1 protein, C elegansEpithelial Sodium ChannelsMEC-10 protein, C elegansMec-4 protein, C elegansMembrane ProteinsCaenorhabditis elegansDEG/ENaC channelsneurodegenerationphysiological suppressorstouch sensitivity

Identifiers

PMID27172609
PMCPMC4825646
OpenAlexW2336538913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.