Evidence map›Paper›PMID 27172431›Full record

ArticleMetabolic syndrome and related disorders2016

Comparison of Endothelial Function in Asian Indians Versus Caucasians.

Snigdha Pusalavidyasagar, Fatima H Sert Kuniyoshi, Abu S M Shamsuzzaman, Prachi Singh, Shantal Maharaj, Pavel Leinveber, Jiri Nykodym, Virend K Somers

Open access · greenAbstract readComparative Study
In one paragraph

Article in Metabolic syndrome and related disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Ten things to know about ten cardiovascular disease risk factors - 2022.American journal of preventive cardiology · 2022
    Review
  3. Ten things to know about ten cardiovascular disease risk factors.American journal of preventive cardiology · 2021
    Review
  4. An Evaluation of the Impact of Therapeutic Phlebotomy on Systemic Endothelial Functions in Polycythemic Patients with the Flow-Mediated Vasodilatation Method.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2017
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Snigdha Pusalavidyasagar1 Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Minnesota , Minneapolis, Minnesota.
Fatima H Sert Kuniyoshi2 Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic , Rochester, Minnesota.
Abu S M Shamsuzzaman3 Cincinnati Children's Hospital, University of Cincinnati , Cincinnati, Ohio.
Prachi Singh2 Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic , Rochester, Minnesota.
Shantal Maharaj2 Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic , Rochester, Minnesota.
Pavel Leinveber2 Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic , Rochester, Minnesota.
Jiri Nykodym2 Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic , Rochester, Minnesota.
Virend K Somers2 Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic , Rochester, Minnesota.
Mayo Clinic · USUniversity of Cincinnati · USUniversity of Minnesota · US

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Disease Mechanisms in Sleep ApneaR01HL065176 · NHLBI · MAYO CLINIC ROCHESTER · PI SOMERS, VIREND K · 1999 to 2021
$5.8M
NCATS NIH HHS UL1 TR000135NHLBI NIH HHS R01 HL065176
6 · The paper itself

Abstract

backgroundAsian Indians have markedly increased mortality due to coronary artery disease (CAD). Impaired endothelial function has been linked to an increased risk of acute cardiovascular events. We tested the hypothesis that endothelial function was attenuated in Asian Indians and Caucasians.

methodsWe studied 14 Asian Indians [mean age: 30 ± 6 years; mean body mass index (BMI): 25 ± 3 kg/m(2)] and 11 Caucasians (mean age: 30 ± 5 years; mean BMI: 26 ± 2 kg/m(2)). All 25 subjects were healthy men and nonsmokers without any history of CAD or diabetes and were not taking medications. Endothelial function was evaluated by ultrasound measures of flow-mediated dilatation (FMD) and endothelium-independent nonflow mediated vasodilatation (NFMD) of the brachial artery, in the morning immediately after awakening (6 a.m.) in a fasting state.

resultsMean age, BMI, apnea-hypopnea index, heart rate, and blood pressure were similar in both groups (P = >0.05). When correcting for body surface area, brachial artery diameter was not different between the two groups (2.1% ± 0.3% vs. 2.2% ± 0.4%; P = 0.29). FMD and NFMD were similar in Asian Indians and Caucasians (5.9% ± 4.1% vs. 5.7% ± 2.6%, P = 0.70; 16.4% ± 8% vs. 14.8% ± 4.1%, P = 0.58, respectively).

conclusionEndothelial function in Asian Indian men is not attenuated in comparison to Caucasian men.

Indexed as

AdultAsian PeopleBrachial ArteryCoronary Artery DiseaseEndothelium, VascularFemaleHumansIndiaMaleRisk FactorsVasodilationWhite PeopleYoung Adult

Identifiers

PMID27172431
PMCPMC5011637
OpenAlexW2368500164

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.