ArticleFertility and sterility2016
Are intracytoplasmic sperm injection and high serum estradiol compounding risk factors for adverse obstetric outcomes in assisted reproductive technology?
Article in Fertility and sterility, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 65 citations in OpenAlex.
- Introduce an optimal method of ovarian stimulation in the polycystic ovarian syndrome affected: a randomized controlled trial.BMC women's health · 2023Trial
- Progesterone-induced endometrial thickness changes do not affect singleton neonatal outcomes in frozen embryo transfer: a retrospective analysis of 6,331 newborns.BMC pregnancy and childbirth · 2026Article
- The Association of Assisted Reproductive Technology with Placental and Umbilical Abnormalities.Journal of personalized medicine · 2025Article
- Assisted reproductive technology-associated risk factors for placenta accreta spectrum after vaginal delivery.Scientific reports · 2024Article
- In vitro fertilization pregnancy may cause fetal thymic volume involution: A case-control study.International journal of reproductive biomedicine · 2023Article
- Mediation effect of pregnancy-induced hypertension on the association between assisted reproductive technology and adverse neonatal outcomes: a population-based study.BMC pregnancy and childbirth · 2023Article
- Young women were associated with higher risk of hypertensive disorders of pregnancy and cesarean section from hormone replaced cycles in frozen-thawed embryo transfer: a retrospective study of 5316 singleton deliveries.Frontiers in endocrinology · 2023Article
- E2 level > 2950 pg/ml on hCG trigger day is an independent predictor for birthweight loss of full-term singletons born after fresh embryo transfers in non-PCOS patients.Reproductive biology and endocrinology : RB&E · 2022Article
- Endometrial thickness is an independent risk factor of hypertensive disorders of pregnancy: a retrospective study of 13,458 patients in frozen-thawed embryo transfers.Reproductive biology and endocrinology : RB&E · 2022Article
- The impact of single-step and sequential embryo culture systems on obstetric and perinatal outcomes in singleton pregnancies: the Massachusetts Outcomes Study of Assisted Reproductive Technology.Fertility and sterility · 2022Article
- The Maternal-Neonatal Outcomes of Twin Pregnancies with Preeclampsia and Their Association with Assisted Reproductive Technology: A Retrospective Study.Diagnostics (Basel, Switzerland) · 2022Article
- Placental histology and pregnancy complications following intracytoplasmic sperm injection for non-male factor infertility.Journal of assisted reproduction and genetics · 2022Article
- Risk factors and clinical outcomes for placenta accreta spectrum with or without placenta previa.Archives of gynecology and obstetrics · 2022Article
- Maternal and obstetric outcomes are influenced by developmental stage and cryopreservation of transferred embryos after clomiphene citrate-based minimal stimulation IVF.Human reproduction open · 2022Article
- Placenta Previa Complicated with Endometriosis: Contemporary Clinical Management, Molecular Mechanisms, and Future Research Opportunities.Biomedicines · 2021Review
- Can Ratios Between Prognostic Factors Predict the Clinical Pregnancy Rate in an IVF/ICSI Program with a GnRH Agonist-FSH/hMG Protocol? An Assessment of 2421 Embryo Transfers, and a Review of the Literature.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- The Impact of Embryo Storage Time on Pregnancy and Perinatal Outcomes and the Time Limit of Vitrification: A Retrospective Cohort Study.Frontiers in endocrinology · 2021Article
- Pregnancy and perinatal outcomes in pregnancies resulting from time interval between a freeze-all cycle and a subsequent frozen-thawed single blastocyst transfer.BMC pregnancy and childbirth · 2020Article
- Association between serum estradiol level on the human chorionic gonadotrophin administration day and clinical outcome.Chinese medical journal · 2019Article
- Ovarian response to stimulation and suboptimal endometrial development are associated with adverse perinatal outcomes in intracytoplasmic sperm injection cycles.JBRA assisted reproduction · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate whether intracytoplasmic sperm injection (ICSI) use and E2 on the final day of assisted reproductive technology (ART) stimulation are associated with adverse obstetric complications related to placentation.
designRetrospective cohort study.
settingLarge private ART practice. PATIENT(S): A total of 383 women who underwent ART resulting in a singleton live birth. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Adverse placental outcomes composed of placenta accreta, placental abruption, placenta previa, intrauterine growth restriction, preeclampsia, gestational hypertension, and small for gestational age infants. RESULT(S): Patients with adverse placental outcomes had higher peak serum E2 levels and were three times more likely to have used ICSI. Adverse placental outcomes were associated with increasing E2 (odds ratio 1.36, 95% confidence interval 1.13-1.65) and ICSI (odds ratio 3.86, 95% confidence interval 1.61-9.27). Adverse outcomes increased when E2 was >3,000 pg/mL and continued to increase in a linear fashion until E2 was >5,000 pg/mL. The association of ICSI with adverse outcomes was independent of male factor infertility. Interaction testing suggested the adverse effect of E2 was primarily seen in ICSI cycles, but not in conventional IVF cycles. Estradiol >5,000 pg/mL was associated with adverse placental events in 36% of all ART cycles and 52% of ICSI cycles. CONCLUSION(S): ICSI and elevated E2 on the day of hCG trigger were associated with adverse obstetric outcomes related to placentation. The finding of a potential interaction of E2 and ICSI with adverse placental events is novel and warrants further investigation.
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Registered trials
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