ArticleG3 (Bethesda, Md.)2016
Third Chromosome Balancer Inversions Disrupt Protein-Coding Genes and Influence Distal Recombination Events in Drosophila melanogaster.
Article in G3 (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Genotoxicity of Artificial Sweetener Combinations: An Integrated Drosophila melanogaster SMART Assay and Computational Modeling Approach.Molecular genetics and genomics : MGG · 2026Article
- Polycomb-mediated transgenerational epigenetic inheritance ofOpen biology · 2025Article
- A genetic basis for facultative parthenogenesis in Drosophila.Current biology : CB · 2023Article
- Drosophila mutants lacking the glial neurotransmitter-modifying enzyme Ebony exhibit low neurotransmitter levels and altered behavior.Scientific reports · 2023Article
- B chromosomes reveal a female meiotic drive suppression system in Drosophila melanogaster.Current biology : CB · 2023Article
- Heterozygous inversion breakpoints suppress meiotic crossovers by altering recombination repair outcomes.PLoS genetics · 2023Article
- Genome sequencing ofGenome research · 2023Article
- Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation.Nature communications · 2022Article
- Mutations ofInternational journal of molecular sciences · 2022Article
- Epistatic selection on a selfisheLife · 2022Article
- Simultaneous cellular and molecular phenotyping of embryonic mutants using single-cell regulatory trajectories.Developmental cell · 2022Article
- Creation of a newmicroPublication biology · 2022Article
- Multiplexed drug-based selection and counterselection genetic manipulations in Drosophila.Cell reports · 2021Article
- A non-coding indel polymorphism in theProceedings. Biological sciences · 2021Article
- A pathway for error-free non-homologous end joining of resected meiotic double-strand breaks.Nucleic acids research · 2021Article
- Identification and Characterization of Breakpoints and Mutations onG3 (Bethesda, Md.) · 2020Article
- Review
- Predicting the Landscape of Recombination Using Deep Learning.Molecular biology and evolution · 2020Article
- The joy of balancers.PLoS genetics · 2019Review
- Highly rearranged chromosomes reveal uncoupling between genome topology and gene expression.Nature genetics · 2019Article
Corrections and comments
- Erratum issuedCorrigendum.2017
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Balancer chromosomes are multiply inverted chromosomes that suppress meiotic crossing over and prevent the recovery of crossover products. Balancers are commonly used in Drosophila melanogaster to maintain deleterious alleles and in stock construction. They exist for all three major chromosomes, yet the molecular location of the breakpoints and the exact nature of many of the mutations carried by the second and third chromosome balancers has not been available. Here, we precisely locate eight of 10 of the breakpoints on the third chromosome balancer TM3, six of eight on TM6, and nine of 11 breakpoints on TM6B We find that one of the inversion breakpoints on TM3 bisects the highly conserved tumor suppressor gene p53-a finding that may have important consequences for a wide range of studies in Drosophila We also identify evidence of single and double crossovers between several TM3 and TM6B balancers and their normal-sequence homologs that have created genetic diversity among these chromosomes. Overall, this work demonstrates the practical importance of precisely identifying the position of inversion breakpoints of balancer chromosomes and characterizing the mutant alleles carried by them.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.