ArticleG3 (Bethesda, Md.)2016
Sex Differences in Drosophila Somatic Gene Expression: Variation and Regulation by doublesex.
Article in G3 (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- A framework for identifying transcript orthologs: the evolution of sex bias in alternative transcript structure in Drosophila.bioRxiv : the preprint server for biology · 2026Article
- Strategies for studying sex differences in brain aging.Trends in genetics : TIG · 2025Review
- The foraging gene coordinates brain and heart networks to modulate socially cued interval timing in Drosophila.PLoS genetics · 2025Article
- Tissue-specific metabolomic signatures for aRoyal Society open science · 2025Article
- Single-nucleus transcriptomics of wing sexual dimorphism and scale cell specialization in sulphur butterflies.PLoS biology · 2025Article
- Cis-regulatory Variation in Relation to Sex and Sexual Dimorphism in Drosophila melanogaster.Genome biology and evolution · 2024Article
- Genetic, Environmental, and Stochastic Components of Lifespan Variability: TheInternational journal of molecular sciences · 2024Review
- Identification of antennal alternative splicing by combining genome and full-length transcriptome analysis inFrontiers in physiology · 2024Article
- Sex-Biased Expression Is Associated With Chromatin State in Drosophila melanogaster and Drosophila simulans.Molecular biology and evolution · 2023Article
- Sex-biased expression is associated with chromatin state inbioRxiv : the preprint server for biology · 2023Article
- Secondary reversion to sexual monomorphism associated with tissue-specific loss of doublesex expression.Evolution; international journal of organic evolution · 2022Article
- Ageing desexualizes theProceedings. Biological sciences · 2022Article
- Interplay between sex determination cascade and major signaling pathways during Drosophila eye development: Perspectives for future research.Developmental biology · 2021Review
- Impact of male trait exaggeration on sex-biased gene expression and genome architecture in a water strider.BMC biology · 2021Article
- Investigation ofeLife · 2021Article
- Doublesex Mediates the Development of Sex-Specific Pheromone Organs in Bicyclus Butterflies via Multiple Mechanisms.Molecular biology and evolution · 2020Article
- Modular tissue-specific regulation ofDevelopment (Cambridge, England) · 2019Article
- Doublesex controls specification and maintenance of the gonad stem cell niches inDevelopment (Cambridge, England) · 2019Article
- Article
- Perturbation of IIS/TOR signaling alters the landscape of sex-differential gene expression in Drosophila.BMC genomics · 2018Article
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Authors and funding
6 authors.
Funding
Abstract
Sex differences in gene expression have been widely studied in Drosophila melanogaster Sex differences vary across strains, but many molecular studies focus on only a single strain, or on genes that show sexually dimorphic expression in many strains. How extensive variability is and whether this variability occurs among genes regulated by sex determination hierarchy terminal transcription factors is unknown. To address these questions, we examine differences in sexually dimorphic gene expression between two strains in Drosophila adult head tissues. We also examine gene expression in doublesex (dsx) mutant strains to determine which sex-differentially expressed genes are regulated by DSX, and the mode by which DSX regulates expression. We find substantial variation in sex-differential expression. The sets of genes with sexually dimorphic expression in each strain show little overlap. The prevalence of different DSX regulatory modes also varies between the two strains. Neither the patterns of DSX DNA occupancy, nor mode of DSX regulation explain why some genes show consistent sex-differential expression across strains. We find that the genes identified as regulated by DSX in this study are enriched with known sites of DSX DNA occupancy. Finally, we find that sex-differentially expressed genes and genes regulated by DSX are highly enriched on the fourth chromosome. These results provide insights into a more complete pool of potential DSX targets, as well as revealing the molecular flexibility of DSX regulation.
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