Evidence map›Paper›PMID 27171862›Full record

ArticleThe Laryngoscope2016

Improved facial nerve identification during parotidectomy with fluorescently labeled peptide.

Timon Hussain, Linda T Nguyen, Michael Whitney, Jonathan Hasselmann, Quyen T Nguyen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. [Near-infrared targeted probe designed for intraoperative imaging of prostatic neurovascular bundles].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023
    Article
  6. Article
  7. Fluorescence labeling of a NaEJNMMI research · 2020
    Article
  8. Review
  9. Management of the facial nerve in parotid cancer: preservation or resection and reconstruction.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Timon HussainDivision of Otolaryngology-Head and Neck Surgery, University of California, San Diego, San Diego, California, U.S.A.
Linda T NguyenDivision of Otolaryngology-Head and Neck Surgery, University of California, San Diego, San Diego, California, U.S.A.
Michael WhitneyDepartment of Pharmacology, University of California, San Diego, San Diego, California, U.S.A.
Jonathan HasselmannDivision of Otolaryngology-Head and Neck Surgery, University of California, San Diego, San Diego, California, U.S.A.
Quyen T NguyenDivision of Otolaryngology-Head and Neck Surgery, University of California, San Diego, San Diego, California, U.S.A.
University of San Diego · US

Funding

Testing Fluorescently Labeled Probes for Nerve Imaging during SurgeryR01EB014929 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NGUYEN, QUYEN · 2012 to 2016
$1.7M
NIBIB NIH HHS R01 EB014929Wellcome Trust
6 · The paper itself

Abstract

objectives/hypothesisAdditional intraoperative guidance could reduce the risk of iatrogenic injury during parotid gland cancer surgery. We evaluated the intraoperative use of fluorescently labeled nerve binding peptide NP41 to aid facial nerve identification and preservation during parotidectomy in an orthotopic model of murine parotid gland cancer. We also quantified the accuracy of intraoperative nerve detection for surface and buried nerves in the head and neck with NP41 versus white light (WL) alone. STUDY

designTwenty-eight mice underwent parotid gland cancer surgeries with additional fluorescence (FL) guidance versus WL reflectance (WLR) alone. Eight mice were used for additional nerve-imaging experiments.

methodsTwenty-eight parotid tumor-bearing mice underwent parotidectomy. Eight mice underwent imaging of both sides of the face after skin removal. Postoperative assessment of facial nerve function measured by automated whisker tracking were compared between FL guidance (n = 13) versus WL alone (n=15). In eight mice, nerve to surrounding tissue contrast was measured under FL versus WLR for all nerve branches detectable in the field of view.

resultsPostoperative facial nerve function after parotid gland cancer surgery tended to be better with additional FL guidance. Fluorescent labeling significantly improved nerve to surrounding tissue contrast for both large and smaller buried nerve branches compared to WLR visualization and improved detection sensitivity and specificity.

conclusionsNP41 FL imaging significantly aids the intraoperative identification of nerve braches otherwise nearly invisible to the naked eye. Its application in a murine model of parotid gland cancer surgery tended to improve functional preservation of the facial nerve. LEVEL OF EVIDENCE: NA Laryngoscope, 126:2711-2717, 2016.

Indexed as

FluoresceinsFluorescent DyesPeptidesAnimalsFacial NerveFacial Nerve InjuriesFemaleIntraoperative ComplicationsMiceMice, NudeMonitoring, IntraoperativeParotid GlandParotid NeoplasmsFluoresceinsFluorescent DyesF-NP41 peptidePeptidesfacial nerveFluorescence-guided surgerynerve labelingparotid gland

Identifiers

PMID27171862
PMCPMC5107163
OpenAlexW2355253964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.