ArticleJournal of acquired immune deficiency syndromes (1999)2016
Chronic Morbidity Among Older Children and Adolescents at Diagnosis of HIV Infection.
Article in Journal of acquired immune deficiency syndromes (1999), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Effect of antiretroviral therapy on longitudinal lung function trends in older children and adolescents with HIV-infection.PloS one · 2019Trial
- The State of the Science on Chronic Comorbidities and Aging in Children and Adolescents with perinatally-acquired HIV.Current HIV/AIDS reports · 2025Review
- Sexual and reproductive health issues facing young people with perinatal HIV infection.AIDS (London, England) · 2025Article
- Correlation of High Resolution CT Findings With Lung Function in Adolescents With Perinatally Acquired HIV on Anti-Retroviral Therapy.Pediatric pulmonology · 2025Article
- High Incidence of Tuberculosis in Young Children Living With HIV in the Western Cape, South Africa.Journal of acquired immune deficiency syndromes (1999) · 2025Article
- Mother-child dyads living with HIV in the Western Cape, South Africa: Undetectable = Undetectable?Journal of the International AIDS Society · 2025Article
- Changes in peripheral quantitative computed tomography measured bone density, size, and strength in Zimbabwean children with and without HIV over one year: a cohort study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Surgery for bronchiectasis in children living with HIV: A case series from a low- to middle-income country.African journal of thoracic and critical care medicine · 2024Article
- Article
- Impaired Bone Architecture in Peripubertal Children With HIV, Despite Treatment With Antiretroviral Therapy: A Cross-Sectional Study From Zimbabwe.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Article
- Effect of azithromycin on incidence of acute respiratory exacerbations in children with HIV taking antiretroviral therapy and co-morbid chronic lung disease: a secondary analysis of the BREATHE trial.EClinicalMedicine · 2021Article
- Shorter Granulocyte Telomeres Among Children and Adolescents With Perinatally Acquired Human Immunodeficiency Virus Infection and Chronic Lung Disease in Zimbabwe.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Prevalence and antimicrobial resistance profiles of respiratory microbial flora in African children with HIV-associated chronic lung disease.BMC infectious diseases · 2021Article
- Time-varying age- and CD4-stratified rates of mortality and WHO stage 3 and stage 4 events in children, adolescents and youth 0 to 24 years living with perinatally acquired HIV, before and after antiretroviral therapy initiation in the paediatric IeDEA Global Cohort Consortium.Journal of the International AIDS Society · 2020Article
- Quantitative CT analysis for bronchiolitis obliterans in perinatally HIV-infected adolescents-comparison with controls and lung function data.European radiology · 2020Article
- Longitudinal Changes in Spirometry in South African Adolescents Perinatally Infected With Human Immunodeficiency Virus Who Are Receiving Antiretroviral Therapy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand.AIDS (London, England) · 2019Article
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundSubstantial numbers of children with HIV present to health care services in older childhood and adolescence, previously undiagnosed. These "slow-progressors" may experience considerable chronic ill health, which is not well characterized. We investigated the prevalence of chronic morbidity among children aged 6-15 years at diagnosis of HIV infection.
methodsA cross-sectional study was performed at 7 primary care clinics in Harare, Zimbabwe. Children aged 6-15 years who tested HIV positive following provider-initiated HIV testing and counseling were recruited. A detailed clinical history and standardized clinical examination was undertaken. The association between chronic disease and CD4 count was investigated using multivariate logistic regression.
resultsOf the 385 participants recruited [52% female, median age 11 years (interquartile range 8-13)], 95% were perinatally HIV infected. The median CD4 count was 375 (interquartile range 215-599) cells per cubic millimeter. Although 78% had previous contact with health care services, HIV testing had not been performed. There was a high burden of chronic morbidity: 23% were stunted, 21% had pubertal delay, 25% had chronic skin disease, 54% had a chronic cough of more than 1 month-duration, 28% had abnormal lung function, and 12% reported hearing impairment. There was no association between CD4 count of <500 cells per cubic millimeter or <350 cells per cubic millimeter with WHO stage or these chronic conditions.
conclusionsIn children with slow-progressing HIV, there is a substantial burden of chronic morbidity even when CD4 count is relatively preserved. Timely HIV testing and prompt antiretroviral therapy initiation are urgently needed to prevent development of chronic complications.
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