Evidence map›Paper›PMID 27171507›Full record

ArticleAnalytical chemistry2016

Organelle-Targeted H2S Probes Enable Visualization of the Subcellular Distribution of H2S Donors.

Leticia A Montoya, Michael D Pluth

Abstract read
In one paragraph

Article in Analytical chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Ribozyme-Catalyzed Site-Specific Labeling of RNA Using OAngewandte Chemie (International ed. in English) · 2025
    Article
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  11. Fluorinated ZnFeACS omega · 2020
    Article
  12. Review
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  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Leticia A MontoyaDepartment of Chemistry and Biochemistry, Institute of Molecular Biology, Materials Science Institute. University of Oregon , Eugene, Oregon 97403, United States.
Michael D PluthDepartment of Chemistry and Biochemistry, Institute of Molecular Biology, Materials Science Institute. University of Oregon , Eugene, Oregon 97403, United States.

Funding

Supplement to: Chemical Tools for Delivery and Detection of Biological Hydrogen SulfideR01GM113030 · NIGMS · UNIVERSITY OF OREGON · PI PLUTH, MICHAEL · 2015 to 2024
$2.8M
NIGMS NIH HHS R01 GM113030
6 · The paper itself

Abstract

Hydrogen sulfide (H2S) is an essential biological signaling molecule in diverse biological regulatory pathways. To provide new chemical tools for H2S imaging, we report here a fluorescent H2S detection platform (HSN2-BG) that is compatible with subcellular localization SNAP-tag fusion protein methodologies and use appropriate fusion protein constructs to demonstrate mitochondrial and lysosomal localization. We also demonstrate the efficacy of this detection platform to image endogenous H2S in Chinese hamster ovary (CHO) cells and use the developed constructs to report on the subcellular H2S distributions provided by common H2S donor molecules AP39, ADT-OH, GYY4137, and diallyltrisulfide (DATS). The developed constructs provide a platform poised to provide new insights into the subcellular distribution of common H2S donors and a useful tool for investigating H2S biochemistry.

Indexed as

AnimalsCells, CulturedCHO CellsCricetulusHumansHydrogen SulfideMolecular ProbesMolecular StructureOrganellesHydrogen SulfideMolecular Probes

Identifiers

PMID27171507
PMCPMC4924525

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.