Evidence map›Paper›PMID 27171109›Full record

ArticleNutrients2016

Diet Quality and Change in Blood Lipids during 16 Years of Follow-up and Their Interaction with Genetic Risk for Dyslipidemia.

Emily Sonestedt, Sophie Hellstrand, Isabel Drake, Christina-Alexandra Schulz, Ulrika Ericson, Joanna Hlebowicz, Margaretha M Persson, Bo Gullberg, Bo Hedblad, Gunnar Engström and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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  9. Chokeberry (Nutrients · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Emily SonestedtDiabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-20502 Malmö, Sweden. emily.sonestedt@med.lu.se.
Sophie HellstrandDiabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-20502 Malmö, Sweden. sophie.hellstrand@med.lu.se.
Isabel DrakeDiabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-20502 Malmö, Sweden. isabel.drake@med.lu.se.
Christina-Alexandra SchulzDiabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-20502 Malmö, Sweden. christina-alexandra.schulz@med.lu.se.
Ulrika EricsonDiabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-20502 Malmö, Sweden. ulrika.ericson@med.lu.se.
Joanna HlebowiczExperimental Cardiovascular Research Unit, Department of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-20502 Malmö, Sweden. joana.hlebowicz@med.lu.se.
Margaretha M PerssonInternal Medicine Research Unit, Department of Clinical Sciences Malmö, Lund University, Inga Marie Nilssons gata 32, SE-20502 Malmö, Sweden. margaretha.m.persson@skane.se.
Bo GullbergNutritional Epidemiology, Department of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-20502 Malmö, Sweden. bo.gullberg@med.lu.se.
Bo HedbladCardiovascular Epidemiology, Department of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-20502 Malmö, Sweden. bo.hedblad@med.lu.se.
Gunnar EngströmCardiovascular Epidemiology, Department of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-20502 Malmö, Sweden. gunnar.engstrom@med.lu.se.
Marju Orho-MelanderDiabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clinical Sciences Malmö, Lund University, Jan Waldenströms gata 35, SE-20502 Malmö, Sweden. marju.orho-melander@med.lu.se.
Lund University · SEMalmö University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A high diet quality according to the Swedish nutrition recommendations is associated with a reduced risk of cardiovascular disease in the population-based Malmö Diet and Cancer cohort. To further clarify this protective association, we examined the association between high diet quality and change in triglycerides, high density lipoprotein-cholesterol (HDL-C), and low density lipoprotein-cholesterol (LDL-C) after 16 years of follow-up in 3152 individuals (61% women; 46-68 years at baseline). In addition, we examined if genetic risk scores composed of 80 lipid-associated genetic variants modify these associations. A diet quality index based on intakes of saturated fat, polyunsaturated fat, sucrose, fiber, fruit and vegetables, and fish was constructed. A high diet quality was associated with lower risk of developing high triglycerides (p = 0.02) and high LDL-C (p = 0.03) during follow-up compared with a low diet quality. We found an association between diet quality and long-term change in HDL-C only among those with lower genetic risk for low HDL-C as opposed to those with higher genetic risk (p-interaction = 0.04). Among those with lower genetic risk for low HDL-C, low diet quality was associated with decreased HDL-C during follow-up (p = 0.05). In conclusion, individuals with high adherence to the Swedish nutrition recommendation had lower risk of developing high triglycerides and LDL-C during 16 years of follow-up.

Indexed as

Genetic Predisposition to DiseaseAgedCohort StudiesCross-Sectional StudiesDietDiet RecordsDyslipidemiasFemaleFollow-Up StudiesHumansLinear ModelsLipidsLipoproteinsMaleMiddle AgedNutritional StatusLipidsLipoproteinsdietepidemiologygeneticslipidslipoproteinsnutrition

Identifiers

PMID27171109
PMCPMC4882687
OpenAlexW2345527540

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.