ArticleInternational journal of molecular sciences2016
Global Metabolic Regulation of the Snow Alga Chlamydomonas nivalis in Response to Nitrate or Phosphate Deprivation by a Metabolome Profile Analysis.
Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 30 citations in OpenAlex.
- A chromosome-level assembly of the alpine snow alga Chloromonas typhlos.Scientific data · 2026Article
- Single-cell ionomes of terrestrial cryosphere algae.Communications earth & environment · 2026Article
- Adaptation versus plastic responses to temperature, light, and nitrate availability in cultured snow algal strains.FEMS microbiology ecology · 2023Article
- Untargeted Metabolomics Unveil Changes in Autotrophic and MixotrophicInternational journal of molecular sciences · 2021Article
- Article
- Altitudinal Zonation of Green Algae Biodiversity in the French Alps.Frontiers in plant science · 2021Article
- Sanguina nivaloides and Sanguina aurantia gen. et spp. nov. (Chlorophyta): the taxonomy, phylogeny, biogeography and ecology of two newly recognised algae causing red and orange snow.FEMS microbiology ecology · 2019Article
- Metabolic Analysis of Four Cultivars ofMetabolites · 2019Article
- Analysis of Metabolites in White Flowers ofMolecules (Basel, Switzerland) · 2018Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present work, Chlamydomonas nivalis, a model species of snow algae, was used to illustrate the metabolic regulation mechanism of microalgae under nutrient deprivation stress. The seed culture was inoculated into the medium without nitrate or phosphate to reveal the cell responses by a metabolome profile analysis using gas chromatography time-of-flight mass spectrometry (GC/TOF-MS). One hundred and seventy-one of the identified metabolites clustered into five groups by the orthogonal partial least squares discriminant analysis (OPLS-DA) model. Among them, thirty of the metabolites in the nitrate-deprived group and thirty-nine of the metabolites in the phosphate-deprived group were selected and identified as "responding biomarkers" by this metabolomic approach. A significant change in the abundance of biomarkers indicated that the enhanced biosynthesis of carbohydrates and fatty acids coupled with the decreased biosynthesis of amino acids, N-compounds and organic acids in all the stress groups. The up- or down-regulation of these biomarkers in the metabolic network provides new insights into the global metabolic regulation and internal relationships within amino acid and fatty acid synthesis, glycolysis, the tricarboxylic acid cycle (TCA) and the Calvin cycle in the snow alga under nitrate or phosphate deprivation stress.
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Registered trials
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