Evidence map›Paper›PMID 27171018›Full record

ArticleRadiology2016

Use of Caval Subtraction 2D Phase-Contrast MR Imaging to Measure Total Liver and Hepatic Arterial Blood Flow: Preclinical Validation and Initial Clinical Translation.

Manil D Chouhan, Rajeshwar P Mookerjee, Alan Bainbridge, Simon Walker-Samuel, Nathan Davies, Steve Halligan, Mark F Lythgoe, Stuart A Taylor

Open access · hybridAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Manil D ChouhanFrom the University College London Centre for Medical Imaging (M.D.C., S.H., S.A.T.), Institute for Liver and Digestive Health (R.P.M., N.D.), and Centre for Advanced Biomedical Imaging (S.W.S., M.F.L.), Division of Medicine, University College London, 250 Euston Rd, 3rd Floor East, London NW1 2PG, England; and Department of Medical Physics, University College London Hospitals NHS Trust, London, England (A.B.).ORCID 0000-0001-5903-1002
Rajeshwar P MookerjeeFrom the University College London Centre for Medical Imaging (M.D.C., S.H., S.A.T.), Institute for Liver and Digestive Health (R.P.M., N.D.), and Centre for Advanced Biomedical Imaging (S.W.S., M.F.L.), Division of Medicine, University College London, 250 Euston Rd, 3rd Floor East, London NW1 2PG, England; and Department of Medical Physics, University College London Hospitals NHS Trust, London, England (A.B.).ORCID 0000-0002-6275-9384
Alan BainbridgeFrom the University College London Centre for Medical Imaging (M.D.C., S.H., S.A.T.), Institute for Liver and Digestive Health (R.P.M., N.D.), and Centre for Advanced Biomedical Imaging (S.W.S., M.F.L.), Division of Medicine, University College London, 250 Euston Rd, 3rd Floor East, London NW1 2PG, England; and Department of Medical Physics, University College London Hospitals NHS Trust, London, England (A.B.).ORCID 0000-0001-7783-7747
Simon Walker-SamuelFrom the University College London Centre for Medical Imaging (M.D.C., S.H., S.A.T.), Institute for Liver and Digestive Health (R.P.M., N.D.), and Centre for Advanced Biomedical Imaging (S.W.S., M.F.L.), Division of Medicine, University College London, 250 Euston Rd, 3rd Floor East, London NW1 2PG, England; and Department of Medical Physics, University College London Hospitals NHS Trust, London, England (A.B.).
Nathan DaviesFrom the University College London Centre for Medical Imaging (M.D.C., S.H., S.A.T.), Institute for Liver and Digestive Health (R.P.M., N.D.), and Centre for Advanced Biomedical Imaging (S.W.S., M.F.L.), Division of Medicine, University College London, 250 Euston Rd, 3rd Floor East, London NW1 2PG, England; and Department of Medical Physics, University College London Hospitals NHS Trust, London, England (A.B.).
Steve HalliganFrom the University College London Centre for Medical Imaging (M.D.C., S.H., S.A.T.), Institute for Liver and Digestive Health (R.P.M., N.D.), and Centre for Advanced Biomedical Imaging (S.W.S., M.F.L.), Division of Medicine, University College London, 250 Euston Rd, 3rd Floor East, London NW1 2PG, England; and Department of Medical Physics, University College London Hospitals NHS Trust, London, England (A.B.).
Mark F LythgoeFrom the University College London Centre for Medical Imaging (M.D.C., S.H., S.A.T.), Institute for Liver and Digestive Health (R.P.M., N.D.), and Centre for Advanced Biomedical Imaging (S.W.S., M.F.L.), Division of Medicine, University College London, 250 Euston Rd, 3rd Floor East, London NW1 2PG, England; and Department of Medical Physics, University College London Hospitals NHS Trust, London, England (A.B.).
Stuart A TaylorFrom the University College London Centre for Medical Imaging (M.D.C., S.H., S.A.T.), Institute for Liver and Digestive Health (R.P.M., N.D.), and Centre for Advanced Biomedical Imaging (S.W.S., M.F.L.), Division of Medicine, University College London, 250 Euston Rd, 3rd Floor East, London NW1 2PG, England; and Department of Medical Physics, University College London Hospitals NHS Trust, London, England (A.B.).
University College London · GBUniversity College London Hospitals NHS Foundation Trust · GB

Funding

Wellcome Trust WT092186
6 · The paper itself

Abstract

Purpose To validate caval subtraction two-dimensional (2D) phase-contrast magnetic resonance (MR) imaging measurements of total liver blood flow (TLBF) and hepatic arterial fraction in an animal model and evaluate consistency and reproducibility in humans. Materials and Methods Approval from the institutional ethical committee for animal care and research ethics was obtained. Fifteen Sprague-Dawley rats underwent 2D phase-contrast MR imaging of the portal vein (PV) and infrahepatic and suprahepatic inferior vena cava (IVC). TLBF and hepatic arterial flow were estimated by subtracting infrahepatic from suprahepatic IVC flow and PV flow from estimated TLBF, respectively. Direct PV transit-time ultrasonography (US) and fluorescent microsphere measurements of hepatic arterial fraction were the standards of reference. Thereafter, consistency of caval subtraction phase-contrast MR imaging-derived TLBF and hepatic arterial flow was assessed in 13 volunteers (mean age, 28.3 years ± 1.4) against directly measured phase-contrast MR imaging PV and proper hepatic arterial inflow; reproducibility was measured after 7 days. Bland-Altman analysis of agreement and coefficient of variation comparisons were undertaken. Results There was good agreement between PV flow measured with phase-contrast MR imaging and that measured with transit-time US (mean difference, -3.5 mL/min/100 g; 95% limits of agreement [LOA], ±61.3 mL/min/100 g). Hepatic arterial fraction obtained with caval subtraction agreed well with those with fluorescent microspheres (mean difference, 4.2%; 95% LOA, ±20.5%). Good consistency was demonstrated between TLBF in humans measured with caval subtraction and direct inflow phase-contrast MR imaging (mean difference, -1.3 mL/min/100 g; 95% LOA, ±23.1 mL/min/100 g). TLBF reproducibility at 7 days was similar between the two methods (95% LOA, ±31.6 mL/min/100 g vs ±29.6 mL/min/100 g). Conclusion Caval subtraction phase-contrast MR imaging is a simple and clinically viable method for measuring TLBF and hepatic arterial flow. Online supplemental material is available for this article.

Indexed as

Liver CirculationAdultAnimalsBlood Flow VelocityContrast MediaFemaleHealthy VolunteersHepatic ArteryHumansMagnetic Resonance ImagingMaleModels, AnimalRatsRats, Sprague-DawleyReproducibility of ResultsSubtraction TechniqueContrast Media

Identifiers

PMID27171018
PMCPMC5015842
OpenAlexW2366594186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.