ReviewSkin appendage disorders2015
Network Meta-Analysis of Onychomycosis Treatments.
Review in Skin appendage disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Topical and device-based treatments for fungal infections of the toenails.The Cochrane database of systematic reviews · 2020Pooled it
- Meta-analysis of the utility of culture, biopsy, and direct KOH examination for the diagnosis of onychomycosis.BMC infectious diseases · 2017Pooled it
- Self-controlled Study of Onychomycosis Treated with Long-pulsed Nd:YAG 1064-nm Laser Combined with Itraconazole.Chinese medical journal · 2016Trial
- Review
- Treatment Options for Onychomycosis: Efficacy, Side Effects, Adherence, Financial Considerations, and Ethics.The Journal of clinical and aesthetic dermatology · 2024Review
- Allylamines, Benzylamines, and Fungal Cell Permeability: A Review of Mechanistic Effects and Usefulness against Fungal Pathogens.Membranes · 2022Review
- Pathogenesis, Immunology and Management of Dermatophytosis.Journal of fungi (Basel, Switzerland) · 2021Review
- A Week of Oral Terbinafine Pulse Regimen Every Three Months to Treat all Dermatophyte Onychomycosis.Journal of fungi (Basel, Switzerland) · 2019Article
- Challenges and Opportunities in the Management of Onychomycosis.Journal of fungi (Basel, Switzerland) · 2018Review
- Patient-Reported Outcomes in Onychomycosis: A Review of Psychometrically Evaluated Instruments in Assessing Treatment Effectiveness.Skin appendage disorders · 2017Review
- A Retrospective Study of Non-thermal Laser Therapy for the Treatment of Toenail Onychomycosis.The Journal of clinical and aesthetic dermatology · 2017Article
- New Antifungal Agents and New Formulations Against Dermatophytes.Mycopathologia · 2017Review
- Nail Society of India (NSI) Recommendations for Pharmacologic Therapy of Onychomycosis.Indian dermatology online journalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany onychomycosis treatments have not been directly compared in head-to-head clinical trials.
objectiveTo determine the relative efficacy of onychomycosis treatments using network meta-analysis (NMA).
methodsWe conducted a systematic review and NMA of mycological cure rates.
resultsNineteen trials were included in the network. Terbinafine 250 mg was significantly superior to all treatments except itraconazole 400 mg pulse therapy. The itraconazole 400 mg pulse regimen was significantly superior to all topicals except efinaconazole 10% nail solution. Itraconazole 200 mg was significantly superior to all topical treatments, while fluconazole 150-450 mg, efinaconazole 10% nail solution, tavaborole 5% nail solution, ciclopirox nail lacquer 8%, terbinafine nail solution, and amorolfine 5% nail lacquer were significantly superior to placebo.
conclusionsNewly developed topicals have improved the odds ratios (ORs) of mycological cure, yet these ORs were not significantly greater than preexisting topical treatments. Further experience with these agents will reveal their clinical significance, and head-to-head trials are warranted. © 2015 S. Karger AG, Basel.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.