SynthesisInternational journal of epidemiology2016
Association of lactase persistence genotype with milk consumption, obesity and blood pressure: a Mendelian randomization study in the 1982 Pelotas (Brazil) Birth Cohort, with a systematic review and meta-analysis.
Synthesis in International journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Pooled it
- Evidence for a causal association between milk intake and cardiometabolic disease outcomes using a two-sample Mendelian Randomization analysis in up to 1,904,220 individuals.International journal of obesity (2005) · 2021Pooled it
- Dairy Consumption and Cardiometabolic Diseases: Systematic Review and Updated Meta-Analyses of Prospective Cohort Studies.Current nutrition reports · 2018Pooled it
- Circulating thrifty microRNA is related to insulin sensitivity, adiposity, and energy metabolism in adults with overweight and obesity: the POUNDS Lost trial.The American journal of clinical nutrition · 2023Trial
- Gut-microbiome-related LCT genotype and 2-year changes in body composition and fat distribution: the POUNDS Lost Trial.International journal of obesity (2005) · 2018Trial
- Dairy consumption and cardiovascular disease risk: a multi-level analysis with inflammatory biomarker mediation.Nutrition & metabolism · 2025Article
- The molecular basis of lactase persistence: Linking genetics and epigenetics.Annals of human genetics · 2025Review
- Advances in Mendelian Randomization Studies of Obesity Over the Past Decade: Uncovering Key Genetic Mechanisms.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- Association of consumption of sugar-sweetened beverages with elevated blood pressure among college students in Yunnan Province, China.Public health nutrition · 2024Article
- Milk and dairy products - a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2024Article
- Intakes of major food groups in China and UK: results from 100,000 adults in the China Kadoorie biobank and UK biobank.European journal of nutrition · 2023Article
- Article
- Using genetic variation to disentangle the complex relationship between food intake and health outcomes.PLoS genetics · 2022Article
- Dairy intake and long-term body weight status in German children and adolescents: results from the DONALD study.European journal of nutrition · 2022Article
- Milk consumption and multiple health outcomes: umbrella review of systematic reviews and meta-analyses in humans.Nutrition & metabolism · 2021Review
- Genetically proxied milk consumption and risk of colorectal, bladder, breast, and prostate cancer: a two-sample Mendelian randomization study.BMC medicine · 2020Article
- Genetic Epidemiology in Latin America: Identifying Strong Genetic Proxies for Complex Disease Risk Factors.Genes · 2020Article
- Genetic determinants of beverage consumption: Implications for nutrition and health.Advances in food and nutrition research · 2019Review
- Adaptation to milking agropastoralism in Chilean goat herders and nutritional benefit of lactase persistence.Annals of human genetics · 2019Article
- Lactose Intolerance, Dairy Avoidance, and Treatment Options.Nutrients · 2018Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundMilk intake has been associated with lower blood pressure (BP) in observational studies, and randomized controlled trials suggested that milk-derived tripeptides have BP-lowering effects. Milk intake has also been associated with body mass index (BMI). Nevertheless, it is unclear whether increasing milk consumption would reduce BP in the general population.
methodsWe investigated the association of milk intake with obesity and BP using genetically-defined lactase persistence (LP) based on the rs4988235 polymorphism in a Mendelian randomization design in the 1982 Pelotas (Southern Brazil) Birth Cohort. These results were combined with published reports identified through a systematic review using meta-analysis.
resultsIn the 1982 Pelotas Birth Cohort, milk intake was 42 [95% confidence interval (CI): 18; 67) ml/day higher in LP individuals. In conventional observational analysis, each 1-dl/day increase in milk intake was associated with -0.26 (95% CI: -0.33; -0.19) kg/m
conclusionsOur study supports that LP is positively associated with obesity, suggesting that the negative association of milk intake with obesity is likely due to limitations of conventional observational studies. Our findings also do not support that increased milk intake leads to lower BP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.