ArticleProceedings. Biological sciences2016
Genetic basis of adult migration timing in anadromous steelhead discovered through multivariate association testing.
Article in Proceedings. Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 173 citations in OpenAlex.
- Genetic Analysis Reveals Climate Exposure and Conservation Opportunities for a Vulnerable Life History in Steelhead (Evolutionary applications · 2026Article
- Temporal Comparison Reveals Weakened Genotype-Phenotype Association at a Major-Effect Locus in Dworshak National Fish Hatchery Steelhead.Evolutionary applications · 2026Article
- Characterizing the Distribution ofEvolutionary applications · 2026Article
- A large-effect locus underlies migration timing in North American Atlantic salmon (Salmo salar).Scientific reports · 2026Article
- Heritable Genetic Effects Caused by a Single Generation of Captive Breeding.Evolutionary applications · 2026Article
- A genome assembly for Lahontan Cutthroat Trout, Oncorhynchus clarkii henshawi.The Journal of heredity · 2026Article
- Defining Conservation Units in a Highly Diverse Species: A Case on Arctic Charr.Evolutionary applications · 2026Article
- Lake sturgeon behavioral diversity in the Laurentian great lakes: migratory patterns across populations and habitats.Movement ecology · 2025Article
- Genetic, phenotypic, and environmental drivers of local adaptation and climate change-induced maladaptation in a migratory songbird.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genomic Basis and Climate Change Vulnerability of Migration Timing in Atlantic Salmon (Evolutionary applications · 2025Article
- A complex mechanism translating variation of a simple genetic architecture into alternative life histories.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Archaeogenomic analysis of Chesapeake Atlantic sturgeon illustrates shaping of its populations in recovery from severe overexploitation.Proceedings. Biological sciences · 2024Article
- Variable parallelism in the genomic basis of age at maturity across spatial scales in Atlantic Salmon.Ecology and evolution · 2024Article
- Genetic parentage reveals the (un)natural history of Central Valley hatchery steelhead.Evolutionary applications · 2024Article
- Genetic variation associated with adult migration timing in lineages of Steelhead and Chinook Salmon in the Columbia River.Evolutionary applications · 2024Review
- Contrasting patterns of sequence variation in steelhead populations reflect distinct evolutionary processes.Evolutionary applications · 2024Article
- A homology guide for Pacific salmon genusEcology and evolution · 2023Article
- Whole genome resequencing identifies local adaptation associated with environmental variation for redband trout.Molecular ecology · 2023Article
- Genomic correlates for migratory direction in a free-ranging cervid.Proceedings. Biological sciences · 2022Article
- Introgression of domesticated salmon changes life history and phenology of a wild salmon population.Evolutionary applications · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migration traits are presumed to be complex and to involve interaction among multiple genes. We used both univariate analyses and a multivariate random forest (RF) machine learning algorithm to conduct association mapping of 15 239 single nucleotide polymorphisms (SNPs) for adult migration-timing phenotype in steelhead (Oncorhynchus mykiss). Our study focused on a model natural population of steelhead that exhibits two distinct migration-timing life histories with high levels of admixture in nature. Neutral divergence was limited between fish exhibiting summer- and winter-run migration owing to high levels of interbreeding, but a univariate mixed linear model found three SNPs from a major effect gene to be significantly associated with migration timing (p < 0.000005) that explained 46% of trait variation. Alignment to the annotated Salmo salar genome provided evidence that all three SNPs localize within a 46 kb region overlapping GREB1-like (an oestrogen target gene) on chromosome Ssa03. Additionally, multivariate analyses with RF identified that these three SNPs plus 15 additional SNPs explained up to 60% of trait variation. These candidate SNPs may provide the ability to predict adult migration timing of steelhead to facilitate conservation management of this species, and this study demonstrates the benefit of multivariate analyses for association studies.
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