ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017
Non-signalling energy use in the developing rat brain.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Intracellular lactate dynamics iniScience · 2025Article
- Elucidating reaction dynamics in a model of human brain energy metabolism.PLoS computational biology · 2025Article
- Effects of actin remodeling inhibitors on cellular energy metabolism of a model marine bivalve, the Pacific oyster.The Journal of experimental biology · 2025Article
- Mitochondrial phosphagen kinases support the volatile power demands of motor nerve terminals.The Journal of physiology · 2023Article
- Actin cytoskeletal dynamics do not impose an energy drain on growth cone bioenergetics.Journal of cell science · 2023Article
- Computational modeling of AMPK and mTOR crosstalk in glutamatergic synapse calcium signaling.NPJ systems biology and applications · 2023Article
- Presynaptic Mitochondrial Volume and Packing Density Scale with Presynaptic Power Demand.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Regulation of the Cerebral Circulation During Development.Comprehensive Physiology · 2021Article
- Cytoskeletal Arrest: An Anoxia Tolerance Mechanism.Metabolites · 2021Review
- Communication consumes 35 times more energy than computation in the human cortex, but both costs are needed to predict synapse number.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Energetics of stochastic BCM type synaptic plasticity and storing of accurate information.Journal of computational neuroscience · 2021Article
- Disturbed Balance of Inhibitory Signaling Links Hearing Loss and Cognition.Frontiers in neural circuits · 2021Article
- Relationship between oxygen consumption and neuronal activity in a defined neural circuit.BMC biology · 2020Article
- The bioenergetics of neuronal morphogenesis and regeneration: Frontiers beyond the mitochondrion.Developmental neurobiology · 2020Review
- Energy-efficient information transfer at thalamocortical synapses.PLoS computational biology · 2019Article
- Quantitative in vivo imaging of neuronal glucose concentrations with a genetically encoded fluorescence lifetime sensor.Journal of neuroscience research · 2019Article
- Local oxygen homeostasis during various neuronal network activity states in the mouse hippocampus.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- The pial vasculature of the mouse develops according to a sensory-independent program.Scientific reports · 2018Article
- The Axon-Myelin Unit in Development and Degenerative Disease.Frontiers in neuroscience · 2018Review
- The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease.Neuron · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Energy use in the brain constrains its information processing power, but only about half the brain's energy consumption is directly related to information processing. Evidence for which non-signalling processes consume the rest of the brain's energy has been scarce. For the first time, we investigated the energy use of the brain's main non-signalling tasks with a single method. After blocking each non-signalling process, we measured oxygen level changes in juvenile rat brain slices with an oxygen-sensing microelectrode and calculated changes in oxygen consumption throughout the slice using a modified diffusion equation. We found that the turnover of the actin and microtubule cytoskeleton, followed by lipid synthesis, are significant energy drains, contributing 25%, 22% and 18%, respectively, to the rate of oxygen consumption. In contrast, protein synthesis is energetically inexpensive. We assess how these estimates of energy expenditure relate to brain energy use in vivo, and how they might differ in the mature brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.