ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2016
Chronic anemic hypoxemia increases plasma glucagon and hepatic PCK1 mRNA in late-gestation fetal sheep.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep.American journal of physiology. Endocrinology and metabolism · 2025Article
- Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets.Journal of developmental origins of health and disease · 2023Article
- Anemic hypoxemia reduces myoblast proliferation and muscle growth in late-gestation fetal sheep.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Late gestation fetal hyperglucagonaemia impairs placental function and results in diminished fetal protein accretion and decreased fetal growth.The Journal of physiology · 2021Article
- Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect.American journal of physiology. Endocrinology and metabolism · 2021Article
- Augmented glucose production is not contingent on high catecholamines in fetal sheep with IUGR.The Journal of endocrinology · 2021Article
- Chorionic somatomammotropin RNA interference alters fetal liver glucose utilization.The Journal of endocrinology · 2020Article
- Effects of chronic hyperinsulinemia on metabolic pathways and insulin signaling in the fetal liver.American journal of physiology. Endocrinology and metabolism · 2020Article
- Article
- Leucine acutely potentiates glucose-stimulated insulin secretion in fetal sheep.The Journal of endocrinology · 2020Article
- A Chronic Fetal Leucine Infusion Potentiates Fetal Insulin Secretion and Increases Pancreatic Islet Size, Vascularity, and β Cells in Late-Gestation Sheep.The Journal of nutrition · 2020Article
- Sustained hypoxemia in late gestation potentiates hepatic gluconeogenic gene expression but does not activate glucose production in the ovine fetus.American journal of physiology. Endocrinology and metabolism · 2019Article
- Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates.Molecular metabolism · 2018Article
- IUGR impairs cardiomyocyte growth and maturation in fetal sheep.The Journal of endocrinology · 2018Article
- Exogenous amino acids suppress glucose oxidation and potentiate hepatic glucose production in late gestation fetal sheep.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Hepatic glucose production (HGP) normally begins just prior to birth. Prolonged fetal hypoglycemia, intrauterine growth restriction, and acute hypoxemia produce an early activation of fetal HGP. To test the hypothesis that prolonged hypoxemia increases factors which regulate HGP, studies were performed in fetuses that were bled to anemic conditions (anemic: n = 11) for 8.9 ± 0.4 days and compared with control fetuses (n = 7). Fetal arterial hematocrit and oxygen content were 32% and 50% lower, respectively, in anemic vs. controls (P < 0.005). Arterial plasma glucose was 15% higher in the anemic group (P < 0.05). Hepatic mRNA expression of phosphonenolpyruvate carboxykinase (PCK1) was twofold higher in the anemic group (P < 0.05). Arterial plasma glucagon concentrations were 70% higher in anemic fetuses compared with controls (P < 0.05), and they were positively associated with hepatic PCK1 mRNA expression (P < 0.05). Arterial plasma cortisol concentrations increased 90% in the anemic fetuses (P < 0.05), but fetal cortisol concentrations were not correlated with hepatic PCK1 mRNA expression. Hepatic glycogen content was 30% lower in anemic vs. control fetuses (P < 0.05) and was inversely correlated with fetal arterial plasma glucagon concentrations. In isolated primary fetal sheep hepatocytes, incubation in low oxygen (3%) increased PCK1 mRNA threefold compared with incubation in normal oxygen (21%). Together, these results demonstrate that glucagon and PCK1 may potentiate fetal HGP during chronic fetal anemic hypoxemia.
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