Evidence map›Paper›PMID 27170570›Full record

ArticleNeurology2016

Quantitative MRI criteria for optic pathway enlargement in neurofibromatosis type 1.

Robert A Avery, Awais Mansoor, Rabia Idrees, Elijah Biggs, Mohammad Ali Alsharid, Roger J Packer, Marius George Linguraru

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Hypothalamic syndrome.Nature reviews. Disease primers · 2022
    Review
  6. Article
  7. Article
  8. Article
  9. Optic Pathway Gliomas in Neurofibromatosis Type 1: An Update: Surveillance, Treatment Indications, and Biomarkers of Vision.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2017
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Robert A AveryFrom the Center for Neuroscience and Behavior (R.A.A., R.J.P.), The Gilbert Family Neurofibromatosis Institute (R.A.A., R.J.P.), the Sheikh Zayed Institute for Pediatric Surgical Innovation (A.M., E.B., M.A.A., M.G.L.), and The Brain Tumor Institute (R.J.P.), Children's National Health System; The George Washington University (R.I.); and The George Washington University School of Medicine and Health Sciences (M.G.L.), Washington, DC. averyr@email.chop.edu.
Awais MansoorFrom the Center for Neuroscience and Behavior (R.A.A., R.J.P.), The Gilbert Family Neurofibromatosis Institute (R.A.A., R.J.P.), the Sheikh Zayed Institute for Pediatric Surgical Innovation (A.M., E.B., M.A.A., M.G.L.), and The Brain Tumor Institute (R.J.P.), Children's National Health System; The George Washington University (R.I.); and The George Washington University School of Medicine and Health Sciences (M.G.L.), Washington, DC.
Rabia IdreesFrom the Center for Neuroscience and Behavior (R.A.A., R.J.P.), The Gilbert Family Neurofibromatosis Institute (R.A.A., R.J.P.), the Sheikh Zayed Institute for Pediatric Surgical Innovation (A.M., E.B., M.A.A., M.G.L.), and The Brain Tumor Institute (R.J.P.), Children's National Health System; The George Washington University (R.I.); and The George Washington University School of Medicine and Health Sciences (M.G.L.), Washington, DC.
Elijah BiggsFrom the Center for Neuroscience and Behavior (R.A.A., R.J.P.), The Gilbert Family Neurofibromatosis Institute (R.A.A., R.J.P.), the Sheikh Zayed Institute for Pediatric Surgical Innovation (A.M., E.B., M.A.A., M.G.L.), and The Brain Tumor Institute (R.J.P.), Children's National Health System; The George Washington University (R.I.); and The George Washington University School of Medicine and Health Sciences (M.G.L.), Washington, DC.
Mohammad Ali AlsharidFrom the Center for Neuroscience and Behavior (R.A.A., R.J.P.), The Gilbert Family Neurofibromatosis Institute (R.A.A., R.J.P.), the Sheikh Zayed Institute for Pediatric Surgical Innovation (A.M., E.B., M.A.A., M.G.L.), and The Brain Tumor Institute (R.J.P.), Children's National Health System; The George Washington University (R.I.); and The George Washington University School of Medicine and Health Sciences (M.G.L.), Washington, DC.
Roger J PackerFrom the Center for Neuroscience and Behavior (R.A.A., R.J.P.), The Gilbert Family Neurofibromatosis Institute (R.A.A., R.J.P.), the Sheikh Zayed Institute for Pediatric Surgical Innovation (A.M., E.B., M.A.A., M.G.L.), and The Brain Tumor Institute (R.J.P.), Children's National Health System; The George Washington University (R.I.); and The George Washington University School of Medicine and Health Sciences (M.G.L.), Washington, DC.
Marius George LinguraruFrom the Center for Neuroscience and Behavior (R.A.A., R.J.P.), The Gilbert Family Neurofibromatosis Institute (R.A.A., R.J.P.), the Sheikh Zayed Institute for Pediatric Surgical Innovation (A.M., E.B., M.A.A., M.G.L.), and The Brain Tumor Institute (R.J.P.), Children's National Health System; The George Washington University (R.I.); and The George Washington University School of Medicine and Health Sciences (M.G.L.), Washington, DC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine quantitative size thresholds for enlargement of the optic nerve, chiasm, and tract in children with neurofibromatosis type 1 (NF1).

methodsChildren 0.5-18.6 years of age who underwent high-resolution T1-weighted MRI were eligible for inclusion. This consisted of children with NF1 with or without optic pathway gliomas (OPGs) and a control group who did not have other acquired, systemic, or genetic conditions that could alter their anterior visual pathway (AVP). Maximum and average diameter and volume of AVP structures were calculated from reconstructed MRI images. Values above the 95th percentile from the controls were considered the threshold for defining an abnormally large AVP measure.

resultsA total of 186 children (controls = 82; NF1noOPG = 54; NF1+OPG = 50) met inclusion criteria. NF1noOPG and NF1+OPG participants demonstrated greater maximum optic nerve diameter and volume, optic chiasm volume, and total brain volume compared to controls (p < 0.05, all comparisons). Total brain volume, rather than age, predicted optic nerve and chiasm volume in controls (p < 0.05). Applying the 95th percentile threshold to all NF1 participants, the maximum optic nerve diameter (3.9 mm) and AVP volumes resulted in few false-positive errors (specificity >80%, all comparisons).

conclusionsQuantitative reference values for AVP enlargement will enhance the development of objective diagnostic criteria for OPGs secondary to NF1.

Indexed as

Magnetic Resonance ImagingAdolescentBrainChildChild, PreschoolFemaleHumansImage Interpretation, Computer-AssistedInfantMaleNeurofibromatosis 1Optic NerveOptic Nerve GliomaOrgan SizeRetrospective StudiesYoung Adult

Identifiers

PMID27170570
PMCPMC4909554

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.