ArticleScientific reports2016
Calorie restriction regulates circadian clock gene expression through BMAL1 dependent and independent mechanisms.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 93 citations in OpenAlex.
- Calorie restriction modulates the transcription of genes related to stress response and longevity in human muscle: The CALERIE study.Aging cell · 2023Trial
- Liver clock: Malalignment and entrainment therapeutics.World journal of gastrointestinal pharmacology and therapeutics · 2026Review
- Comparative Pan- and Phylo-Genomic Analysis of Ideonella and Thermobifida Strains: Dissemination of Biodegradation Potential and Genomic Divergence.Biochemical genetics · 2026Article
- The importance of sex dimorphism in liver metabolism and progressive liver diseases.Biology of sex differences · 2025Review
- Tuned by time: the role of circadian rhythms in metabolic energy sensing and chronotherapy.Annals of medicine · 2025Review
- Role of circadian CLOCK signaling in cellular senescence.Biogerontology · 2025Review
- Isolation and characterization of a bacteria of Cupriavidus genus from Indian Himalayan region and its evaluation for production of Poly-3-hydroxybutyrate.Archives of microbiology · 2025Article
- Article
- Weight loss increases circadian gene expression and emotional well-being in individuals with obesity.Frontiers in nutrition · 2025Article
- The circadian rhythm: A key variable in aging?Aging cell · 2024Article
- Effects of Dietary Protein Intake Levels on Peripheral Circadian Rhythm in Mice.International journal of molecular sciences · 2024Article
- Lack of Bmal1 leads to changes in rhythmicity and impairs motivation towards natural stimuli.Open biology · 2024Article
- Sexual dimorphism of circadian liver transcriptome.iScience · 2024Article
- Review
- Circadian mechanisms in adipose tissue bioenergetics and plasticity.Genes & development · 2023Review
- Is time-restricted eating (8/16) beneficial for body weight and metabolism of obese and overweight adults? A systematic review and meta-analysis of randomized controlled trials.Food science & nutrition · 2023Review
- Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals.Cell metabolism · 2023Article
- Molecular crosstalk between circadian clock and cancer and therapeutic implications.Frontiers in nutrition · 2023Review
- The circadian transcription factor ARNTL2 is regulated by weight-loss interventions in human white adipose tissue and inhibits adipogenesis.Cell death discovery · 2022Article
- Circadian clock controls rhythms in ketogenesis by interfering with PPARα transcriptional network.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Feeding behavior, metabolism and circadian clocks are interlinked. Calorie restriction (CR) is a feeding paradigm known to extend longevity. We found that CR significantly affected the rhythms in the expression of circadian clock genes in mice on the mRNA and protein levels, suggesting that CR reprograms the clocks both transcriptionally and post-transcriptionally. The effect of CR on gene expression was distinct from the effects of time-restricted feeding or fasting. Furthermore, CR affected the circadian output through up- or down-regulation of the expression of several clock-controlled transcriptional factors and the longevity candidate genes. CR-dependent effects on some clock gene expression were impaired in the liver of mice deficient for BMAL1, suggesting importance of this transcriptional factor for the transcriptional reprogramming of the clock, however, BMAL1- independent mechanisms also exist. We propose that CR recruits biological clocks as a natural mechanism of metabolic optimization under conditions of limited energy resources.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.