Evidence map›Paper›PMID 27170518›Full record

ArticleThe British journal of ophthalmology2017

Quantification of retinal layer thickness changes in acute macular neuroretinopathy.

Marion R Munk, Marco Beck, Simone Kolb, Michael Larsen, Steffen Hamann, Christophe Valmaggia, Martin S Zinkernagel

Abstract read
In one paragraph

Article in The British journal of ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Acute macular neuroretinopathy in dengue virus serotype 1.American journal of ophthalmology case reports · 2022
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marion R MunkDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Switzerland.
Marco BeckDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Switzerland.
Simone KolbDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Switzerland.
Michael LarsenDepartment of Ophthalmology, Rigshospitalet-Glostrup, University of Copenhagen, Glostrup, Denmark.
Steffen HamannDepartment of Ophthalmology, Rigshospitalet-Glostrup, University of Copenhagen, Glostrup, Denmark.
Christophe ValmaggiaDepartment of Ophthalmology, Kantonspital St. Gallen, St. Gallen, Switzerland.
Martin S ZinkernagelDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo quantitatively evaluate retinal layer thickness changes in acute macular neuroretinopathy (AMN).

methodsAMN areas were identified using near-infrared reflectance (NIR) images. Intraretinal layer segmentation using Heidelberg software was performed. The inbuilt ETDRS -grid was moved onto the AMN lesion and the mean retinal layer thicknesses of the central grid were recorded and compared with the corresponding area of the fellow eye at initial presentation and during follow-up.

resultsEleven patients were included (mean age 26±6 years). AMN lesions at baseline had a significantly thinner outer nuclear layer (ONL) (51±21 µm vs 73±17 µm, p=0.002). The other layers, including inner nuclear layer (37±8 µm vs 38±6 µm, p=0.9) and outer plexiform layer (OPL) (45±19 µm vs 33±16 µm, p=0.1) did not show significant differences between the study eyes and fellow eyes. Adjacent to NIR image lesions, areas of OPL thickening were identified (study eye: 50±14 µm vs fellow eye: 39±16 µm, p=0.005) with corresponding thinning of ONL (study eye: 52±16 µm vs fellow eye: 69±16 µm, p=0.002).

conclusionsAMN presents with characteristic quantitative retinal changes and the extent of the lesion may be more extensive than initially presumed from NIR image lesions.

Indexed as

AdolescentAdultFemaleHumansMacula LuteaMaleRetinaRetinal DiseasesRetinal Ganglion CellsRetrospective StudiesTomography, Optical CoherenceVisual AcuityYoung AdultImagingMacula

Identifiers

PMID27170518
PMCPMC5293849

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.