Evidence map›Paper›PMID 27170489›Full record

ArticleThe Journal of veterinary medical science2016

ANTXR-1 and -2 independent modulation of a cytotoxicity mediated by anthrax toxin in human cells.

Daisuke Fujikura, Kochi Toyomane, Kozue Kamiya, Memi Mutoh, Etsuko Mifune, Miyuki Ohnuma, Hideaki Higashi

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of veterinary medical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Daisuke FujikuraDivision of Infection and Immunity, Research Center for Zoonosis Control, Hokkaido University, Kita-20, Nishi-10, Kita-ku, Sapporo, Hokkaido 001-0020, Japan.
Kochi Toyomane
Kozue Kamiya
Memi Mutoh
Etsuko Mifune
Miyuki Ohnuma
Hideaki Higashi
Hokkaido University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several animal models have shown that anthrax toxin (ATX) elicits a cytotoxic effect on host cells through anthrax toxin receptor (ANTXR) function. In this study, compared with mouse cells, cells obtained from humans exhibited low sensitivity to ATX-mediated cytotoxicity, and the sensitivity was not correlated with expression levels of ANTXRs. ATX treatment also induced a cytotoxic effect in other cultured human cells, human embryonic kidney (HEK) 293 cells, that express ANTXRs at undetectable levels. Furthermore, ectopic expression of ANTXRs in HEK293 cells did not affect the sensitivity to ATX treatment. These findings suggest that there is an ANTXR-independent cytotoxic mechanism in human cells.

Indexed as

AnimalsAntigens, BacterialBacterial ToxinsCell LineCell SurvivalDose-Response Relationship, DrugFlow CytometryHEK293 CellsHumansMiceMicrofilament ProteinsMonocytesNeoplasm ProteinsReceptors, Cell SurfaceReceptors, Peptideanthrax toxinAntigens, BacterialANTXR1 protein, humanANTXR2 protein, humanBacterial ToxinsMicrofilament ProteinsNeoplasm ProteinsReceptors, Cell SurfaceReceptors, Peptide

Identifiers

PMID27170489
PMCPMC5053933
OpenAlexW2365177495

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.