Evidence map›Paper›PMID 27170370›Full record

ArticleBioscience reports2016

Increased expression of SET domain-containing proteins and decreased expression of Rad51 in different classes of renal cell carcinoma.

Si Liu, Yiyang Li, Hongmei Xu, Kaichen Wang, Nan Li, Jia Li, Tao Sun, Ying Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Si LiuDepartment of Urology, The First Hospital of Jilin University, Jilin 130021, China.
Yiyang LiDepartment of Gynaecology, The First Hospital of Jilin University, Jilin 130021, China.
Hongmei XuDepartment of Obstetrics, The First Hospital of Jilin University, Jilin 130021, China.
Kaichen WangDepartment of Urology, The Third Hospital of Jilin University, Jilin 130031, China.
Nan LiIntensive Care Unit, The First Hospital of Jilin University, Jilin 130021, China.
Jia LiDepartment of Nephrology, The First Hospital of Jilin University, Jilin 130021, China.
Tao SunDepartment of Nephrology, The First Hospital of Jilin University, Jilin 130021, China.
Ying XuDepartment of Nephrology, The First Hospital of Jilin University, Jilin 130021, China yingxu_jilin@126.com.
First Hospital of Jilin University · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, we aimed to examine whether SET domain-containing methyltransferases are up-regulated in different classes of renal cell carcinoma. We immunoblotted against SET domain and quantified the expression of these modular domains. Furthermore, we examined the expression of Rad51, the key protein that confers genomic stability. There was enhanced expression of SET domain-containing histone methyltransferases in whole lysates of all classes of renal carcinoma. In metastatic high grade clear cell carcinoma, this expression was more pronounced. Though we could not demonstrate direct correlation, we showed that epigenetic modification by methylation is associated with decreased genomic translation of Rad51.

Indexed as

Epigenesis, GeneticAdultAgedAged, 80 and overCarcinoma, Renal CellFemaleGene Expression Regulation, NeoplasticGenomic InstabilityHistone-Lysine N-MethyltransferaseHistone MethyltransferasesHistonesHumansMaleMethyltransferasesMiddle AgedNeoplasm MetastasisHistone-Lysine N-MethyltransferaseHistone MethyltransferasesHistonesMethyltransferasesRad51 Recombinaseepigeneticgenome instabilityhistonemetastasismethyltransferaserenal cell cancer

Identifiers

PMID27170370
PMCPMC5293581
OpenAlexW2357136598

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.