Evidence map›Paper›PMID 27170266›Full record

ArticleThe world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry2017

Testing differential susceptibility: Plasticity genes, the social environment, and their interplay in adolescent response inhibition.

Jennifer S Richards, Alejandro Arias Vásquez, Daan van Rooij, Dennis van der Meer, Barbara Franke, Pieter J Hoekstra, Dirk J Heslenfeld, Jaap Oosterlaan, Stephen V Faraone, Catharina A Hartman and 1 more

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In one paragraph

Article in The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Jennifer S Richardsa Department of Cognitive Neuroscience , Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center , Nijmegen , The Netherlands.
Alejandro Arias Vásquezc Department of Human Genetics , Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center , Nijmegen , The Netherlands.
Daan van Rooija Department of Cognitive Neuroscience , Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center , Nijmegen , The Netherlands.
Dennis van der Meere Department of Psychiatry , University of Groningen, University Medical Center Groningen , The Netherlands.
Barbara Frankec Department of Human Genetics , Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center , Nijmegen , The Netherlands.
Pieter J Hoekstrae Department of Psychiatry , University of Groningen, University Medical Center Groningen , The Netherlands.
Dirk J Heslenfeldf Department of Clinical Neuropsychology , VU University Amsterdam , Amsterdam , The Netherlands.
Jaap Oosterlaanf Department of Clinical Neuropsychology , VU University Amsterdam , Amsterdam , The Netherlands.
Stephen V Faraoneg SUNY Upstate Medical University Center, Departments of Psychiatry and of Neuroscience and Physiology, Syracuse , USA and the K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen , Bergen , Norway.
Catharina A Hartmane Department of Psychiatry , University of Groningen, University Medical Center Groningen , The Netherlands.
Jan K Buitelaara Department of Cognitive Neuroscience , Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center , Nijmegen , The Netherlands.
Radboud University Medical Center · NLUniversity of Groningen · NLKarakter · NLRadboud University Nijmegen · NLSUNY Upstate Medical University · USUniversity Medical Center Groningen · NL

Funding

Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
International Multi-Center ADHD Genetics ProjectR01MH062873 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI FARAONE, STEPHEN V · 2002 to 2007
$7.2M
Quantifying the impact of rare mutations on ADHDR01MH094469 · NIMH · BROAD INSTITUTE, INC. · PI NEALE, BENJAMIN MICHAEL · 2012 to 2015
$2.4M
COLLABORATIVE ADHD GENETICS CONFERENCER13MH059126 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI FARAONE, STEPHEN V · 1999 to 2014
$957k
Analysis of an ADHD Whole Genome Association ScanR01MH081803 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI FARAONE, STEPHEN V · 2007 to 2007
$157k
NIBIB NIH HHS U54 EB020403NIMH NIH HHS R01 MH062873NIMH NIH HHS R01 MH081803NIMH NIH HHS R01 MH094469NIMH NIH HHS R13 MH059126
6 · The paper itself

Abstract

objectivesImpaired inhibitory control is a key feature of attention-deficit/hyperactivity disorder (ADHD). We investigated gene-environment interaction (GxE) as a possible contributing factor to response inhibition variation in context of the differential susceptibility theory. This states individuals carrying plasticity gene variants will be more disadvantaged in negative, but more advantaged in positive environments.

methodsBehavioural and neural measures of response inhibition were assessed during a Stop-signal task in participants with (N = 197) and without (N = 295) ADHD, from N = 278 families (age M = 17.18, SD =3.65). We examined GxE between candidate plasticity genes (DAT1, 5-HTT, DRD4) and social environments (maternal expressed emotion, peer affiliation).

resultsA DRD4 × Positive peer affiliation interaction was found on the right fusiform gyrus (rFG) activation during successful inhibition. Further, 5-HTT short allele carriers showed increased rFG activation during failed inhibitions. Maternal warmth and positive peer affiliation were positively associated with right inferior frontal cortex activation during successful inhibition. Deviant peer affiliation was positively related to the error rate.

conclusionsWhile a pattern of differential genetic susceptibility was found, more clarity on the role of the FG during response inhibition is warranted before firm conclusions can be made. Positive and negative social environments were related to inhibitory control. This extends previous research emphasizing adverse environments.

Indexed as

Attention Deficit Disorder with HyperactivityGene-Environment InteractionInhibition, PsychologicalInterpersonal RelationsMother-Child RelationsSocial EnvironmentAdolescentCerebral CortexDopamine Plasma Membrane Transport ProteinsExpressed EmotionFemaleGenetic Predisposition to DiseaseHumansMagnetic Resonance ImagingMaleNeuronal PlasticityDopamine Plasma Membrane Transport ProteinsDRD4 protein, humanReceptors, Dopamine D4Serotonin Plasma Membrane Transport ProteinsSLC6A3 protein, humanSLC6A4 protein, humanADHDfunctional MRIgene–environment interactionresponse inhibitionsocial environment

Identifiers

PMID27170266
PMCPMC5435559
OpenAlexW2385074134

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.