Evidence map›Paper›PMID 27170222›Full record

ArticleMagnetic resonance in medicine2017

Insight into the quantitative metrics of chemical exchange saturation transfer (CEST) imaging.

Hye-Young Heo, Dong-Hoon Lee, Yi Zhang, Xuna Zhao, Shanshan Jiang, Min Chen, Jinyuan Zhou

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

  1. Effective Modeling of Continuous WaveMagnetic resonance in medicine · 2026
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  16. Study of Power Equivalent Continuous Approximation Based on the Recent Consensus Recommendations for Brain Tumor Imaging with Pulsed Chemical Exchange Saturation Transfer at 3T.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Article
  17. Article
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  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hye-Young HeoDivison of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
Dong-Hoon LeeDivison of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
Yi ZhangDivison of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
Xuna ZhaoDivison of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
Shanshan JiangDivison of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
Min ChenDepartment of Radiology, Beijing Hospital, Beijing, China.
Jinyuan ZhouDivison of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.

Funding

TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1M
Amide Proton Transfer (APT) MRI of Brain Tumors at 3T and 7TR01EB009731 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI ZHOU, JINYUAN · 2009 to 2016
$2.9M
Academic-Industrial Partnership to Develop Clinical Brain Cancer ImagingR01CA166171 · NCI · JOHNS HOPKINS UNIVERSITY · PI VAN ZIJL, PETER CM, ZHOU, JINYUAN · 2013 to 2017
$2.4M
US-China Collaborative Research on Stroke ImagingR01NS083435 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ZHOU, JINYUAN · 2013 to 2015
$588k
Molecular MRI of Radiation Necrosis in Preclinical ModelsR21EB015555 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI ZHOU, JINYUAN · 2012 to 2013
$447k
NCI NIH HHS R01 CA166171NIBIB NIH HHS P41 EB015909NIBIB NIH HHS R01 EB009731NIBIB NIH HHS R21 EB015555NINDS NIH HHS R01 NS083435
6 · The paper itself

Abstract

purposeTo evaluate the reliability of four CEST imaging metrics for brain tumors, at varied saturation power levels and magnetic field strengths (3-9.4 Tesla (T)).

methodsA five-pool proton exchange model (free water, semisolid, amide, amine, and NOE-related protons) was used for the simulations. For the in vivo study, eight glioma-bearing rats were scanned at 4.7 T. The CEST ratio (CESTR), CESTR normalized with the reference value (CESTR

resultsThe simulated CEST signal intensities using MTR

conclusionsCEST metrics must be carefully selected based on the different experimental settings. CESTR and CESTR

Indexed as

AlgorithmsAnimalsBrain NeoplasmsComputer SimulationGliomaHumansImage EnhancementImage Processing, Computer-AssistedMagnetic Resonance SpectroscopyNeoplasm TransplantationRatsRats, NudeReproducibility of ResultsAPTbrain tumorCESTMTRNOE

Identifiers

PMID27170222
PMCPMC5107181

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.