ArticleScientific reports2016
Application of iridium(III) complex in label-free and non-enzymatic electrochemical detection of hydrogen peroxide based on a novel "on-off-on" switch platform.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 29 citations in OpenAlex.
- Editorial: Immunomodulatory role of metalloproteases in chronic inflammatory diseases.Frontiers in immunology · 2023Article
- G-quadruplex-selective iridium(III) complex as a novel electrochemiluminescence probe for switch-on assay of double-stranded DNA.Analytical and bioanalytical chemistry · 2022Article
- Laser-Induced Synthesis of Composite Materials Based on Iridium, Gold and Platinum for Non-Enzymatic Glucose Sensing.Materials (Basel, Switzerland) · 2020Article
- One-step Synthesized Silver Nanoparticles Using Isoimperatorin: Evaluation of Photocatalytic, and Electrochemical Activities.Scientific reports · 2020Article
- Cardiac Troponin I: Ultrasensitive Detection Using Faradaic Electrochemical Impedance.ACS omega · 2018Article
- Nonenzymatic sensing of hydrogen peroxide using a glassy carbon electrode modified with graphene oxide, a polyamidoamine dendrimer, and with polyaniline deposited by the Fenton reaction.Mikrochimica acta · 2018Article
- A cyclometalated iridium(III) complex used as a conductor for the electrochemical sensing of IFN-γ.Scientific reports · 2017Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We herein report a label-free and non-enzymatic electrochemical sensor for the highly sensitive detection of hydrogen peroxide (H2O2) based on a novel "on-off-on" switch system. In our design, MB was used as an electron mediator to accelerate the electron transfer while AuNPs was used to amplify the electrochemical signal due to its excellent biocompatibility and good conductivity. The "switch-off" state was achieved by introducing the guanine-rich capture probe (CP) and an iridium complex onto the electrode surface to form a hydrophobic layer, which then hinders electron transfer. Upon addition of H2O2, fenton reaction occurs and produces OH• in the presence of Fe(2+). The OH• cleaves the CP into DNA fragments, thus resulting in the release of CP and iridium complex from the sensing interface, recovering the electrochemical signal to generate a "switch-on" state. Based on this novel switch system, a detection limit as low as 3.2 pM can be achieved for H2O2 detection. Moreover, satisfactory results were obtained by using this method for the detection of H2O2 in sterilized milk. To the best of our knowledge, this is the first G-quadruplex-based electrochemical sensor using an iridium(III) complex.
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Registered trials
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