SynthesisEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2016
The causative agents in infective endocarditis: a systematic review comprising 33,214 cases.
Synthesis in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 3 syntheses or guidelines pooled it, 161 citations in OpenAlex.
- Multivalvular vs single-valve infective endocarditis: a systematic review and meta-analysis.Future cardiology · 2025Pooled it
- A comparison of different antibiotic regimens for the treatment of infective endocarditis.The Cochrane database of systematic reviews · 2020Pooled it
- Epidemiology of infective endocarditis beforeTherapeutic advances in cardiovascular diseasePooled it
- Infective Endocarditis of Transcatheter Aortic Valve Replacement and Transcatheter Edge-to-Edge Repair Devices.JACC. Advances · 2026Review
- Quantitative Assessment of Primary Colonizer Adhesion on Different Resin-Based Restorative Materials Using SYBR Green qPCR.Dentistry journal · 2026Article
- Impact of Heart Disease and Multimorbidity on Oral Frailty in Japanese Community-Dwelling Older Adults.Circulation reports · 2026Article
- Infectious Endocarditis Caused by Multidrug-resistant Corynebacterium striatum in an Immunocompetent Host without a History of Cardiac Disease.Internal medicine (Tokyo, Japan) · 2026Article
- The evolving story ofFrontiers in microbiology · 2026Review
- Management of infective endocarditis in a secondary care trust: a service evaluation of treatment outcomes and multidisciplinary involvement.Access microbiology · 2026Article
- Clinical Characteristics, Microbiology, and In-Hospital Outcomes of Infective Endocarditis at a Tertiary Cardiac Center in Saudi Arabia: A Retrospective Cohort Study.Journal of the Saudi Heart Association · 2026Article
- Systematic analysis of the type VII secretion system inFrontiers in microbiology · 2026Article
- Microbial Transitions in Infective Endocarditis Influence the Spectrum of Clinical Features and Functional Outcomes.Circulation reports · 2025Article
- Antimicrobial Sol-Gel Glassy Surfaces for Modification of Dental Implant Abutments to Reduce Microbial Adhesion.Gels (Basel, Switzerland) · 2025Article
- Trends in Epidemiology, Clinical Characteristics, and Outcomes of Infective Endocarditis: A 16-Year Nationwide Cohort Study in Korea.Journal of Korean medical science · 2025Article
- Advances and Prospects in the Diagnosis and Treatment of Blood Culture-Negative Infective Endocarditis.Reviews in cardiovascular medicine · 2025Review
- Predictors of mortality inThe Journal of international medical research · 2025Observational
- A 29-Year-Old Man with Uncorrected Congenital Patent Ductus Arteriosus Presenting with Heart Failure and Pulmonary Artery Vegetations Removed During Surgery: A Case Report.The American journal of case reports · 2025Article
- 2-[18F]F-p-Aminobenzoic Acid Specifically Detects Infective Endocarditis in Positron Emission Tomography.The Journal of infectious diseases · 2025Article
- Impact of insulin storage and syringe reuse on insulin sterility in diabetes mellitus patients in Mwanza Tanzania.Scientific reports · 2025Article
- Etiological Aspects of Infectious Endocarditis in a Tertiary Hospital in Northeastern Romania.Medicina (Kaunas, Lithuania) · 2025Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infective endocarditis (IE) incidence remains high with considerable fatality rates; guidelines for prophylaxis against IE are currently under review in some settings which highlights the importance of maintaining up-to-date epidemiological estimates about the most common microbial causes. The objective of this systematic review, following PRISMA guidelines, was to identify the most common microbial causes of IE in recent years. Medline was searched from January 1, 2003 to March 31, 2013 for all articles containing the term "infective endocarditis". All relevant studies reporting diagnostic results were included. Special patient subpopulations were assessed separately. A total of 105 studies were included, from 36 countries, with available data on a total of 33,214 cases. Staphylococcus aureus was found to be the most common microorganism, being the most frequent in 54.3 % of studies (N = 57) (and in 55.4 % of studies using Duke's criteria for diagnosis [N = 51]). Viridans group streptococci (VGS), coagulase-negative staphylococci (CoNS), Enterococcus spp and Streptococcus bovis were among the most common causes. S. aureus was the most common pathogen in almost all population subgroups; however, this was not the case in patients with implantable devices, prosthetic valves, or immunocompromised non-HIV, as well as in the sub-group from Asia, emphasizing that a global one-size-fits-all approach to the management of suspected IE is not appropriate. This review provides an evidence-based map of the most common causative agents of IE, highlighting S. aureus as the leading cause in the 21st century. The changing epidemiology of IE in some patient sub-groups in the last decade and the very high number of microbiologically undiagnosed cases (26.6 %) suggest the need to revisit IE prophylaxis and diagnostic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.