Evidence map›Paper›PMID 27169703›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2016

From normal response to clinical problem: definition and clinical features of fear of cancer recurrence.

Sophie Lebel, Gozde Ozakinci, Gerald Humphris, Brittany Mutsaers, Belinda Thewes, Judith Prins, Andreas Dinkel, Phyllis Butow, University of Ottawa Fear of Cancer Recurrence Colloquium attendees

3 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 311 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
311citing papers in PubMed, 17 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04287218 nacompletednot on this mapstarted 2023, after this paper: background citation

A Randomized Controlled Trial Comparing the Efficacy of Therapist Guided Internet-delivered Cognitive Therapy (TG-iConquerFear) With Augmented Treatment as Usual in Reducing Fear of Cancer Recurrence in Danish Colorectal Cancer Survivors

TypeinterventionalSponsorVejle HospitalRan2023 to 2026Enrolled95ConditionsFear of Cancer Recurrence, Colorectal Cancer, Anxiety, Health AnxietyArmsTG-iConquerFear, aTAU
NCT06817694 narecruitingnot on this mapstarted 2026, after this paper: background citation

Cognitive Behavioral Therapy for Fear of Cancer Recurrence in Women With BRCA1/2 Gene

TypeinterventionalSponsorCHU de Quebec-Universite LavalRan2026 to 2028Enrolled250ConditionsBreast Cancer Susceptibility Gene (BRCA1) Mutation, BRCA2 Mutation, Fear of Cancer RecurrenceArmsCognitive-behavioral group therapy
NCT06872840 narecruitingnot on this mapstarted 2025, after this paper: background citation

Addressing Fear of Cancer Recurrence in Parents of Pediatric Cancer Survivors: Adapting The Fear Of Recurrence Therapy (FORT) for Parents and Establishing Acceptability and Feasibility

TypeinterventionalSponsorUniversity of OttawaRan2025 to 2027Enrolled36ConditionsCancer, Parent, Fear of Cancer Recurrence, CBTArmsParent Fear of Recurrence Therapy (Parent-FORT)
3 · Its place in the literature

Who cites it

311 citing papers in PubMed, 17 syntheses or guidelines pooled it.

  1. How prevalent is fear of cancer recurrence beyond 5 years: a systematic review of validated assessments across tumour types.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  10. Non-gastrointestinal symptom burden following colorectal cancer treatment-a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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  11. Psychosocial experiences of breast cancer survivors: a meta-review.Journal of cancer survivorship : research and practice · 2024
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  17. Fear of cancer recurrence and PSA anxiety in patients with prostate cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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251 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Sophie LebelUniversity of Ottawa, 136 Jean Jacques Lussier, room 4016, Ottawa, Canada, K1N6N5. slebel@uottawa.ca.
Gozde OzakinciUniversity of St Andrews, Cambridge, UK.
Gerald HumphrisUniversity of St Andrews, Cambridge, UK.
Brittany MutsaersUniversity of Ottawa, 136 Jean Jacques Lussier, room 4016, Ottawa, Canada, K1N6N5.
Belinda ThewesRadboud University, Nijmegen, Netherlands.
Judith PrinsRadboud University, Nijmegen, Netherlands.
Andreas DinkelTechnische Universität München, Munich, Germany.
Phyllis ButowUniversity of Sydney, Sydney, Australia.
University of Ottawa Fear of Cancer Recurrence Colloquium attendees

Funding

CIHR PCS 142019
6 · The paper itself

Abstract

purposeResearch to date on fear of cancer recurrence (FCR) shows that moderate to high FCR affects 22-87 % of cancer survivors and is associated with higher psychological morbidity (Simard et al J Cancer Surviv 7:300-322, 2013). Despite growing research interest in FCR, the lack of consensus on its definition and characteristics when it reaches a clinical level has impeded knowledge transfer into patient services.

methodsIn order to address these gaps, expert researchers, policy makers, trainees, and patient advocates attended a 2-day colloquium at the University of Ottawa in August 2015. A Delphi method was used to identify the most relevant definition of FCR, and the attendees generated possible diagnostic characteristics of clinical FCR.

resultsAfter three rounds of discussion and voting, the attendees reached consensus on a new definition of FCR: "Fear, worry, or concern relating to the possibility that cancer will come back or progress." Regarding clinical FCR, five possible characteristics were proposed: (1) high levels of preoccupation, worry, rumination, or intrusive thoughts; (2) maladaptive coping; (3) functional impairments; (4) excessive distress; and (5) difficulties making plans for the future.

conclusionsThe new proposed definition of FCR reflects the broad spectrum in which patients experience FCR. A consensual definition of FCR and the identification of the essential characteristics of clinical FCR are necessary to accurately and consistently measure FCR severity and to develop effective interventions to treat FCR. We hope this broad definition can encourage further research and the development of inclusive policies for all cancer patients and survivors who are struggling with this issue.

Indexed as

FearFemaleHumansNeoplasm Recurrence, LocalSurvivorsClinical fear of cancer recurrenceDefinitionDelphi studyExpert opinionFear of cancer recurrencePsychosocial oncology

Identifiers

PMID27169703

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.