ArticleBMC women's health2016
Recurrence of cervical intraepithelial lesions after thermo-coagulation in HIV-positive and HIV-negative Nigerian women.
Article in BMC women's health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Use of Thermal Ablation in Low-Resource Settings: Experience From Three Multicenter Noninferiority Randomized Clinical Trials.JCO global oncology · 2025Pooled it
- Residual or Recurrent Precancerous Lesions After Treatment of Cervical Lesions in Human Immunodeficiency Virus-infected Women: A Systematic Review and Meta-analysis of Treatment Failure.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Pooled it
- Safety and Acceptability of Three Ablation Treatments for High-Grade Cervical Precancer: Early Data From a Randomized Noninferiority Clinical Trial.JCO global oncology · 2022Trial
- Barriers and facilitators of adherence to cervical cancer screening follow-up among women living with HIV in South Ethiopia: a qualitative study.BMC primary care · 2026Article
- Prevalence and associated factors of persistent precancerous lesions among women treated for cervical lesions in Addis Ababa, Ethiopia.The oncologist · 2025Article
- Observational
- Barriers to adherence of posttreatment follow-up after positive primary cervical cancer screening in Ethiopia: a mixed-methods study.The oncologist · 2025Article
- Impact of telephone reminders on posttreatment follow-up among women treated for cervical precancers in Cameroon: A randomized controlled trial.Gynecologic oncology reports · 2025Article
- Barriers to adherence to cervical cancer screening care in Northern Tanzania.The oncologist · 2025Article
- Article
- Cervical Precancer Treatment Outcomes in Cameroon.International journal of MCH and AIDS · 2024Article
- Efficacy of thermal ablation for treatment of biopsy-confirmed high-grade cervical precancer among women living with HIV in Kenya.International journal of cancer · 2023Article
- Factors associated with adherence to post-treatment follow-up among a cohort of women with acetic acid/Lugol's iodine positive lesions of the cervix in Cameroon: A retrospective cohort study.Gynecologic oncology reports · 2023Article
- "When You Have Gotten Help, That Means You Were Strong": A Qualitative Study of Experiences in a "Screen and Treat" Program for Cervical Cancer Prevention in Malawi.Journal of cancer education : the official journal of the American Association for Cancer Education · 2022Article
- Health care workers' experiences with implementation of "screen and treat" for cervical cancer prevention in Malawi: A qualitative study.Implementation science communications · 2020Article
- Modeling spatial access to cervical cancer screening services in Ondo State, Nigeria.International journal of health geographics · 2020Article
- Acceptability and safety of thermal ablation for the treatment of precancerous cervical lesions in Honduras.Tropical medicine & international health : TM & IH · 2019Article
- Data Resource Profile: Cardiovascular H3Africa Innovation Resource (CHAIR).International journal of epidemiology · 2019Article
- Ablative Therapies for Cervical Intraepithelial Neoplasia in Low-Resource Settings: Findings and Key Questions.Journal of global oncology · 2018Review
- A review of screening strategies for cervical cancer in human immunodeficiency virus-positive women in sub-Saharan Africa.International journal of women's health · 2017Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundThe burden of cervical cancer remains huge globally, more so in sub-Saharan Africa. Effectiveness of screening, rates of recurrence following treatment and factors driving these in Africans have not been sufficiently studied. The purpose of this study therefore was to investigate factors associated with recurrence of cervical intraepithelial lesions following thermo-coagulation in HIV-positive and HIV-negative Nigerian women using Visual Inspection with Acetic Acid (VIA) or Lugol's Iodine (VILI) for diagnosis.
methodsA retrospective cohort study was conducted, recruiting participants from the cervical cancer "see and treat" program of IHVN. Data from 6 sites collected over a 4-year period was used. Inclusion criteria were: age ≥18 years, baseline HIV status known, VIA or VILI positive and thermo-coagulation done. Logistic regression was performed to examine the proportion of women with recurrence and to examine factors associated with recurrence.
resultsOut of 177 women included in study, 67.8 % (120/177) were HIV-positive and 32.2 % (57/177) were HIV-negative. Recurrence occurred in 16.4 % (29/177) of participants; this was 18.3 % (22/120) in HIV-positive women compared to 12.3 % (7/57) in HIV-negative women but this difference was not statistically significant (p-value 0.31). Women aged ≥30 years were much less likely to develop recurrence, adjusted OR = 0.34 (95 % CI = 0.13, 0.92). Among HIV-positive women, CD4 count <200cells/mm(3) was associated with recurrence, adjusted OR = 5.47 (95 % CI = 1.24, 24.18).
conclusionRecurrence of VIA or VILI positive lesions after thermo-coagulation occurs in a significant proportion of women. HIV-positive women with low CD4 counts are at increased risk of recurrent lesions and may be related to immunosuppression.
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