Evidence map›Paper›PMID 27169624›Full record

ArticleDalton transactions (Cambridge, England : 2003)2016

Incorporation of gallium-68 into the crystal structure of Prussian blue to form K(68)GaxFe1-x[Fe(CN)6] nanoparticles: toward a novel bimodal PET/MRI imaging agent.

Murthi S Kandanapitiye, Matthew D Gott, Andrew Sharits, Silvia S Jurisson, Patrick M Woodward, Songping D Huang

Abstract read
In one paragraph

Article in Dalton transactions (Cambridge, England : 2003), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Radiolabeled inorganic nanoparticles for positron emission tomography imaging of cancer: an overview.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Murthi S KandanapitiyeDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA. shuang1@kent.edu.
Matthew D GottDepartment of Chemistry, University of Missouri, Columbia, MO 65211, USA.
Andrew SharitsDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.
Silvia S JurissonDepartment of Chemistry, University of Missouri, Columbia, MO 65211, USA.
Patrick M WoodwardDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA.
Songping D HuangDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH 44240, USA. shuang1@kent.edu.

Funding

Prussian Blue Nanoparticles as Cellular T1 MRI Contrast AgentsR21CA143408 · NCI · KENT STATE UNIVERSITY · PI HUANG, SONGPING D · 2011 to 2013
$501k
NCI NIH HHS R21 CA143408
6 · The paper itself

Abstract

Similarity between the Ga(+) ion and the Fe(3+) ion allows for partial replacement of Fe(3+) ions with Ga(3+) ions in the Fe(iii) crystallographic positions in Prussian blue (PB) to form various solid solutions KGaxFe1-x[Fe(CN)6] (0 < x < 1). Such solid solutions possess very high thermodynamic stability as expected from the parent PB structure. Consequently, a simple one-step (68)Ga-labeling method was developed for preparing a single-phase nanoparticulate bimodal PET/MRI imaging agent based on the PB structural platform. Unlike the typical (68)Ga-labelling reaction based on metal complexation, this novel chelator-free (68)Ga-labeling reaction was shown to be kinetically fast under the acidic conditions. The Ga(3+) ion does not hydrolyze, and affords the (68)Ga-labelled PB nanoparticles, which are easy to purify and have extremely high stability against radionuclidic leaching in aqueous solution.

Identifiers

PMID27169624
PMCPMC4922916

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.