Evidence map›Paper›PMID 27169485›Full record

ArticleEpidemiology and infection2016

Salivary IgA against sporozoite-specific embryogenesis-related protein (TgERP) in the study of horizontally transmitted toxoplasmosis via T. gondii oocysts in endemic settings.

B M Mangiavacchi, F P Vieira, L M G Bahia-Oliveira, D Hill

Abstract read
In one paragraph

Article in Epidemiology and infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Limited value of current and newFrontiers in parasitology · 2023
    Article
  4. Two small-molecule inhibitors ofFrontiers in cellular and infection microbiology · 2023
    Article
  5. Article
  6. Mining the Proteome ofAnimals : an open access journal from MDPI · 2022
    Review
  7. Identification of Oocyst-DrivenMicroorganisms · 2021
    Review
  8. Key Limitations and New Insights Into theFrontiers in cellular and infection microbiology · 2020
    Review
  9. Article
  10. 2019 AAFP Feline Zoonoses Guidelines.Journal of feline medicine and surgery · 2019
    Article
  11. Environmental transmission ofFood and waterborne parasitology · 2019
    Review
  12. Rapid inactivation ofFood and waterborne parasitology · 2018
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

B M MangiavacchiLaboratório de Biologia do Reconhecer,Centro de Biociências e Biotecnologia,Universidade Estadual do Norte Fluminense Darcy Ribeiro,Campos dos Goytacazes,Rio de Janeiro,Brazil.
F P VieiraLaboratório de Biologia do Reconhecer,Centro de Biociências e Biotecnologia,Universidade Estadual do Norte Fluminense Darcy Ribeiro,Campos dos Goytacazes,Rio de Janeiro,Brazil.
L M G Bahia-OliveiraLaboratório de Imunoparasitologia,Universidade Federal do Rio de Janeiro,Macaé,Rio de Janeiro,Brazil.
D HillAnimal Parasitic Diseases Laboratory,Beltsville Agricultural Research Center,United States Department of Agriculture,Beltsville,MD,USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to contribute to the better understanding of the relative epidemiological importance of different modes of infection with respect to horizontal transmission of Toxoplasma gondii in endemic settings. We investigated the prevalence of salivary IgA against a sporozoite-specific embryogenesis-related protein (TgERP) in a highly endemic area for toxoplasmosis in Brazil in order to pinpoint parasite transmission via oocysts. Prevalence calculated by salivary IgA specific to TgERP was compared to the prevalence calculated by serum IgG against both TgERP and tachyzoites (in conventional serological tests). Prevalence calculated by different serological and salivary parameters varied in the studied age groups. However, for the 15-21 years age group, values for T. gondii prevalence estimated by conventional serological tests and by anti-TgERP salivary IgA were similar; i.e. 68·7% and 66·6% or 66·7%, respectively, using two different cut-off parameters for salivary IgA anti-TgERP. Furthermore, salivary IgA anti-TgERP for this age group presented the highest specificity (93·33%), sensitivity (93·94%), and likelihood (14·09) compared to all the other age groups. These data demonstrate the importance of age for salivary IgA investigation against TgERP to estimate the mode of T. gondii transmission in endemic settings.

Indexed as

AdolescentAdultAgedAntibodies, ProtozoanBrazilChildChild, PreschoolFemaleHumansImmunoglobulin AInfantInfant, NewbornMaleMiddle AgedOocystsPrevalenceAntibodies, ProtozoanImmunoglobulin AProtozoan ProteinsDiagnosisoocystssalivary IgAToxoplasma gondiiwaterborne infections

Identifiers

PMID27169485
PMCPMC9150463

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.