ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2016
Statin Use and Hospital Length of Stay Among Adults Hospitalized With Community-acquired Pneumonia.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Reducing the complications from community acquired pneumonia: a review.Journal of thoracic disease · 2026Review
- Impact of Statin Therapy on Clinical Outcomes of Patients Hospitalised with Skin and Soft Tissue Infections.Journal of clinical medicine · 2026Article
- Penicillin Allergy Evaluation Access: A National Survey.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Effects of statins on clinical outcomes in hospitalized patients with community-acquired pneumonia.The Journal of international medical research · 2020Article
- Seasonal and pandemic influenza: 100 years of progress, still much to learn.Mucosal immunology · 2020Review
- Targeted antioxidants as therapeutics for treatment of pneumonia in the elderly.Translational research : the journal of laboratory and clinical medicine · 2020Review
- Should We Tip Our CAPs to Statins?American journal of respiratory and critical care medicine · 2019Article
- Multicenter Study of the Real-World Use of Ceftaroline versus Vancomycin for Acute Bacterial Skin and Skin Structure Infections.Antimicrobial agents and chemotherapy · 2019Article
- Statin Use and the Point Prevalence of Antibiotics in Ambulatory Patients with Diabetes in the National Health and Nutrition Examination Survey (NHANES) 2003-2012.Antibiotics (Basel, Switzerland) · 2019Article
- Article
- The Use of Statins and Risk of Community-Acquired Pneumonia.Current infectious disease reports · 2017Review
- Advances in community-acquired pneumonia.Therapeutic advances in infectious diseaseReview
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Authors and funding
15 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundPrior retrospective studies suggest that statins may benefit patients with community-acquired pneumonia (CAP) due to antiinflammatory and immunomodulatory effects. However, prospective studies of the impact of statins on CAP outcomes are needed. We determined whether statin use was associated with improved outcomes in adults hospitalized with CAP.
methodsAdults aged ≥18 years hospitalized with CAP were prospectively enrolled at 3 hospitals in Chicago, Illinois, and 2 hospitals in Nashville, Tennessee, from January 2010-June 2012. Adults receiving statins before and throughout hospitalization (statin users) were compared with those who did not receive statins (nonusers). Proportional subdistribution hazards models were used to examine the association between statin use and hospital length of stay (LOS). In-hospital mortality was a secondary outcome. We also compared groups matched on propensity score.
resultsOf 2016 adults enrolled, 483 (24%) were statin users; 1533 (76%) were nonusers. Statin users were significantly older, had more comorbidities, had more years of education, and were more likely to have health insurance than nonusers. Multivariable regression demonstrated that statin users and nonusers had similar LOS (adjusted hazard ratio [HR], 0.99; 95% confidence interval [CI], .88-1.12), as did those in the propensity-matched groups (HR, 1.03; 95% CI, .88-1.21). No significant associations were found between statin use and LOS or in-hospital mortality, even when stratified by pneumonia severity.
conclusionsIn a large prospective study of adults hospitalized with CAP, we found no evidence to suggest that statin use before and during hospitalization improved LOS or in-hospital mortality.
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