ArticleSchizophrenia bulletin2017
Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations.
Article in Schizophrenia bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Linking Polygenic Risk of Schizophrenia to Variation in Magnetic Resonance Imaging Brain Measures: A Comprehensive Systematic Review.Schizophrenia bulletin · 2024Pooled it
- Recent developments in imaging transcriptomics for psychiatric disorders.Psychoradiology · 2026Review
- Fronto-Thalamic Structural Connectivity Associated With Schizotypy, a Psychosis Risk Phenotype, in Nonclinical Subjects.Schizophrenia bulletin · 2025Article
- Unveiling Promising Neuroimaging Biomarkers for Schizophrenia Through Clinical and Genetic Perspectives.Neuroscience bulletin · 2024Review
- Schizophrenia Polygenic Risk During Typical Development Reflects Multiscale Cortical Organization.Biological psychiatry global open science · 2023Article
- Prognostic associations of cortical gyrification in minimally medicated schizophrenia in an early intervention setting.Schizophrenia (Heidelberg, Germany) · 2022Article
- Predicting Treatment Response in Schizophrenia With Magnetic Resonance Imaging and Polygenic Risk Score.Frontiers in genetics · 2022Article
- Cortical Gyrification, Psychotic-Like Experiences, and Cognitive Performance in Nonclinical Subjects.Schizophrenia bulletin · 2020Article
- Multimodal data revealed different neurobiological correlates of intelligence between males and females.Brain imaging and behavior · 2020Article
- Polygenic evidence and overlapped brain functional connectivities for the association between chronic pain and sleep disturbance.Translational psychiatry · 2020Article
- Article
- A Prospective Longitudinal Investigation of Cortical Thickness and Gyrification in Schizophrenia.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2020Article
- Psychotic symptoms are associated with lower cortical folding in youth at risk for mental illnessJournal of psychiatry & neuroscience : JPN · 2020Article
- Effects of the Openness to Experience Polygenic Score on Cortical Thickness and Functional Connectivity.Frontiers in neuroscience · 2020Article
- Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk.JAMA psychiatry · 2019Article
- A controlled comparison of thickness, volume and surface areas from multiple cortical parcellation packages.BMC bioinformatics · 2019Article
- MRI Indices of Cortical Development in Young People With Psychotic Experiences: Influence of Genetic Risk and Persistence of Symptoms.Schizophrenia bulletin · 2019Article
- Development of the cerebral cortex and the effect of the intrauterine environment.The Journal of physiology · 2018Review
- A Schizophrenia-Related Genetic-Brain-Cognition Pathway Revealed in a Large Chinese Population.EBioMedicine · 2018Article
- Recent Advances in the Genetics of Schizophrenia.Molecular neuropsychiatry · 2018Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is highly heritable, whereas the effect of each genetic variant is very weak. Since clinical heterogeneity and complexity of schizophrenia is high, considerable effort has been made to relate genetic variants to underlying neurobiological aspects of schizophrenia (endophenotypes). Given the polygenic nature of schizophrenia, our goal was to form a measure of additive genetic risk and explore its relationship to cortical morphology. Utilizing the data from a recent genome-wide association study that included nearly 37 000 cases of schizophrenia, we computed a polygenic risk score (PGRS) for each subject in 2 independent and healthy general populations. We then investigated the effect of polygenic risk for schizophrenia on cortical gyrification calculated from 3.0T structural imaging data in the discovery dataset (N = 315) and replication dataset (N = 357). We found a consistent effect of the polygenic risk for schizophrenia on cortical gyrification in the inferior parietal lobules in 2 independent general-population samples. A higher PGRS was significantly associated with a lower local gyrification index in the bilateral inferior parietal lobles, where case-control differences have been reported in previous studies on schizophrenia. Our findings strongly support the effectiveness of both PGRSs and endophenotypes in establishing the genetic architecture of psychiatry. Our findings may provide some implications regarding individual differences in the genetic risk for schizophrenia to cortical morphology and brain development.
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