Evidence map›Paper›PMID 27169104›Full record

ArticleAdvanced biomedical research2016

Analysis of the T354P mutation of the sodium/iodide cotransporter gene in children with congenital hypothyroidism due to dyshormonogenesis.

Hajar Miranzadeh-Mahabadi, Modjtaba Emadi-Baygi, Parvaneh Nikpour, Neda Mostofizade, Silva Hovsepian, Mahin Hashemipour

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced biomedical research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hajar Miranzadeh-MahabadiDepartment of Genetics, School of Basic Sciences, Shahrekord University, Shahrekord, Iran.
Modjtaba Emadi-BaygiDepartment of Genetics, School of Basic Sciences, Shahrekord University, Shahrekord, Iran; Institute of Biotechnology, School of Basic Sciences, Shahrekord University, Shahrekord, Iran.
Parvaneh NikpourApplied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Genetics and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Neda MostofizadeDepartment of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Silva HovsepianChild Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Mahin HashemipourChild Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan University of Medical Sciences · IRShahrekord University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCongenital hypothyroidism (CH) due to the thyroid dyshormonogenesis is more prevalent in Iran in comparison to other countries. Sodium iodide symporter (NIS) is one of the plasma membrane glycoproteins that is located on the basolateral side of thyroid follicular cells and mediates active I(-) trapping into these cells. Playing a prominent role in thyroid hormone synthesis, NIS gene mutations can be a cause of permanent CH with the etiology of dyshormonogenesis. The aim of this study was to investigate the occurrence of T354P mutation of the NIS gene, in a group of children affected with permanent CH in Isfahan. MATERIALS AND

methodsThirty-five patients with the etiology of dyshormonogenesis, and 35 healthy children, collected between 2002 and 2011 in Isfahan Endocrine and Metabolism Research Center, were examined for T354P mutation of the NIS gene by direct polymerase chain reaction-sequencing method.

resultsNo T354P mutation was detected in any of the studied children.

conclusionsMore subjects with confirmed iodide transport defects should be screened for detecting the frequency of different reported NIS gene mutations in our population.

Indexed as

Congenital hypothyroidismdyshormonogenesismutationsodium iodide symporter geneT354P

Identifiers

PMID27169104
PMCPMC4854026
OpenAlexW2340544494

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