ArticlePeerJ2016
NADPH-dependent thioredoxin reductase C plays a role in nonhost disease resistance against Pseudomonas syringae pathogens by regulating chloroplast-generated reactive oxygen species.
Article in PeerJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- The important role of chloroplasts in plant immunity.Plant communications · 2025Review
- Comparative Proteomic Analysis of Popcorn Genotypes Identifies Differentially Accumulated Proteins Associated with Resistance Pathways to Southern Leaf Blight Disease.Plants (Basel, Switzerland) · 2025Article
- Metabolome profiling dissects the oat (Avena sativa L.) innate immune response to Pseudomonas syringae pathovars.PloS one · 2025Article
- Light- and Relative Humidity-Regulated Hypersensitive Cell Death and Plant Immunity in Chinese Cabbage Leaves by a Non-adapted Bacteria Xanthomonas campestris pv. vesicatoria.The plant pathology journal · 2024Article
- NTRC and thioredoxins m1/m2 underpin the light acclimation of plants on proteome and metabolome levels.Plant physiology · 2024Article
- Functional role of formate dehydrogenase 1 (FDH1) for host and nonhost disease resistance against bacterial pathogens.PloS one · 2022Article
- Function of Chloroplasts in Plant Stress Responses.International journal of molecular sciences · 2021Review
- A chloroplast redox relay adapts plastid metabolism to light and affects cytosolic protein quality control.Plant physiology · 2021Article
- Host GRXC6 restricts Tomato yellow leaf curl virus infection by inhibiting the nuclear export of the V2 protein.PLoS pathogens · 2021Article
- Redox regulation of chloroplast metabolism.Plant physiology · 2021Review
- The Chloroplast Reactive Oxygen Species-Redox System in Plant Immunity and Disease.Frontiers in plant science · 2020Review
- Insights into the function of NADPH thioredoxin reductase C (NTRC) based on identification of NTRC-interacting proteins in vivo.Journal of experimental botany · 2019Article
- Chloroplast Redox Regulatory Mechanisms in Plant Adaptation to Light and Darkness.Frontiers in plant science · 2019Review
- The major leaf ferredoxin Fd2 regulates plant innate immunity in Arabidopsis.Molecular plant pathology · 2018Article
- Cellulose-Derived Oligomers Act as Damage-Associated Molecular Patterns and Trigger Defense-Like Responses.Plant physiology · 2017Article
- Article
- Arabidopsis thimet oligopeptidases are redox-sensitive enzymes active in the local and systemic plant immune response.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chloroplasts are cytoplasmic organelles for photosynthesis in eukaryotic cells. In addition, recent studies have shown that chloroplasts have a critical role in plant innate immunity against invading pathogens. Hydrogen peroxide is a toxic by-product from photosynthesis, which also functions as a signaling compound in plant innate immunity. Therefore, it is important to regulate the level of hydrogen peroxide in response to pathogens. Chloroplasts maintain components of the redox detoxification system including enzymes such as 2-Cys peroxiredoxins (2-Cys Prxs), and NADPH-dependent thioredoxin reductase C (NTRC). However, the significance of 2-Cys Prxs and NTRC in the molecular basis of nonhost disease resistance is largely unknown. We evaluated the roles of Prxs and NTRC using knock-out mutants of Arabidopsis in response to nonhost Pseudomonas syringae pathogens. Plants lacking functional NTRC showed localized cell death (LCD) accompanied by the elevated accumulation of hydrogen peroxide in response to nonhost pathogens. Interestingly, the Arabidopsis ntrc mutant showed enhanced bacterial growth and disease susceptibility of nonhost pathogens. Furthermore, the expression profiles of the salicylic acid (SA) and jasmonic acid (JA)-mediated signaling pathways and phytohormone analyses including SA and JA revealed that the Arabidopsis ntrc mutant shows elevated JA-mediated signaling pathways in response to nonhost pathogen. These results suggest the critical role of NTRC in plant innate immunity against nonhost P. syringae pathogens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.