ArticleAmerican journal of clinical and experimental immunology2016
Analysis of subsets of B cells, Breg, CD4Treg and CD8Treg cells in adult patients with primary selective IgM deficiency.
Article in American journal of clinical and experimental immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Secreted IgM modulates IL-10 expression in B cells.Nature communications · 2024Article
- Selective IgM Deficiency: Evidence, Controversies, and Gaps.Diagnostics (Basel, Switzerland) · 2023Review
- Members of the Regulatory Lymphocyte Club in Common Variable Immunodeficiency.Frontiers in immunology · 2022Review
- Collagenous Gastritis in Primary Selective IgM Deficiency: Transition to EBV+ Gastric Adenocarcinoma.Case reports in immunology · 2021Article
- Neurolisteriosis in a previously asymptomatic patient with serum IgM deficiency: a case report.BMC neurology · 2020Article
- Review
- Acute-onset Autoimmune Hepatitis in a Patient with Selective Immunoglobulin M Deficiency.Internal medicine (Tokyo, Japan) · 2019Article
- Challenges in investigating patients with isolated decreased serum IgM: The SIMcal study.Scandinavian journal of immunology · 2019Article
- Defining Primary Selective IgM Deficiency.Journal of clinical immunology · 2019Article
- Autoimmunity and immunodeficiency at the crossroad: autoimmune disorders as the presenting feature of selective IgM deficiency.BMJ case reports · 2019Article
- Comprehensive clinical and immunological features of 62 adult patients with selective primary IgM deficiency.American journal of clinical and experimental immunology · 2019Article
- IgAλ monoclonal gammopathy of undetermined significance (MGUS) associated with primary selective IgM deficiency.American journal of clinical and experimental immunology · 2019Article
- Phenotypical T Cell Differentiation Analysis: A Diagnostic and Predictive Tool in the Study of Primary Immunodeficiencies.Frontiers in immunology · 2019Article
- Truly selective primary IgM deficiency is probably very rare.Clinical and experimental immunology · 2018Review
- Selective IgM Deficiency: Clinical and Laboratory Features of 17 Patients and a Review of the Literature.Journal of clinical immunology · 2017Review
- Selective IgM Deficiency-An Underestimated Primary Immunodeficiency.Frontiers in immunology · 2017Review
- Natural IgM and the Development of B Cell-Mediated Autoimmune Diseases.Critical reviews in immunology · 2016Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary selective IgM deficiency (SIGMD) is a rare and recently IUIS-recognized primary immunodeficiency disease with increased susceptibility to infections, allergy, and autoimmune diseases. The pathogenesis of selective IgM remains unclear. The objective of the study was to understand the pathogenesis of selective IgM deficiency via a comprehensive analysis of subsets of B cells, naïve and memory subsets of CD4+ and CD8+ T cells, and Breg, CD4Treg, and CD8Treg cells. Twenty adult patients with SIGMD (serum IgM 4 mg/dl-32 mg/dl) and age-and gender-matched healthy controls were studied. Naïve B cells, transitional B cells, marginal zone B cells, germinal center B cells, IgM memory B cells, switched memory B cells, plasmablasts, CD21(low) B cells, B1 cells, CXCR3+ naive and memory B cells; naïve, central memory, and effector memory subsets of CD4+ and CD8+ T cells, and CD4Treg, CD8Treg and Breg were phenotypically analyzed using multicolor flow cytometry. A significant increase in CD21(low), IgM memory B cells, Breg and CD8Treg, and a significant decreased in germinal center B cells, and CXCR3+ naïve and memory B cells were observed in SIGMD. These alterations in subsets of B cells, and Breg and CD8Treg cells may play a role in the pathogenesis of SIGMD.
Indexed as
Identifiers
27168952PMC4858603W2412281289What OpenQuestion holds
Registered trials
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