Evidence map›Paper›PMID 27168942›Full record

ReviewMaternal health, neonatology and perinatology2016

New approaches to management of neonatal hypoglycemia.

Paul J Rozance, William W Hay

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Maternal health, neonatology and perinatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03448965 (Glycemic Disorders in Low Birth Weight Babies), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03448965 unknown statusnot on this mapstarted 2018, after this paper: background citation

Glycemic Disorders in Low Birth Weight Babies

TypeobservationalSponsorAssiut UniversityRan2018 to 2019Enrolled100ConditionsHypoglycemia in Newborn Infants, HyperglycemiaArmsrandom blood sugar
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Glucose Gel as a Potential Alternative Treatment to Infant Formula for Neonatal Hypoglycaemia in Australia.International journal of environmental research and public health · 2018
    Trial
  3. Review
  4. Article
  5. Article
  6. Neonatal hypoglycaemia.BMJ medicine · 2024
    Review
  7. A quality improvement initiative for neonatal hypoglycemia screening and management in a level III neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Prevalence and safety of diazoxide in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2018
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Enhanced insulin secretion and insulin sensitivity in young lambs with placental insufficiency-induced intrauterine growth restriction.American journal of physiology. Regulatory, integrative and comparative physiology · 2017
    Article
  20. Neonatal risk mortality scores as predictors for health-related quality of life of infants treated in NICU: a prospective cross-sectional study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Paul J RozancePerinatal Research Center, Department of Pediatrics, University of Colorado School of Medicine, 13243 E 23rd Ave, MS F441, Aurora, CO 80045 USA.
William W HayPerinatal Research Center, Department of Pediatrics, University of Colorado School of Medicine, 13243 E 23rd Ave, MS F441, Aurora, CO 80045 USA.
University of Colorado Denver · US

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
Training Program in Perinatal Biology and MedicineT32HD007186 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Paul Joseph Rozance · 1985 to 2026
$6.5M
Nutrient Coordination of Pancreatic Vasculature and Beta-CellsR01DK088139 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI ROZANCE, PAUL JOSEPH · 2011 to 2020
$5.1M
Training in Basic and Translational Child Health ResearchK12HD068372 · NICHD · UNIVERSITY OF COLORADO DENVER · PI DANIELS, STEPHEN R · 2011 to 2020
$3.7M
NICHD NIH HHS K12 HD068372NICHD NIH HHS T32 HD007186NIDDK NIH HHS R01 DK088139
6 · The paper itself

Abstract

Despite being a very common problem after birth, consensus on how to manage low glucose concentrations in the first 48 h of life has been difficult to establish and remains a debated issue. One of the reasons for this is that few studies have provided the type of data needed to establish a definitive approach agreed upon by all. However, some recent publications have provided much needed primary data to inform this debate. These publications have focused on aspects of managing low blood glucose concentrations in the patients most at-risk for asymptomatic hypoglycemia-those born late-preterm, large for gestational age, small for gestational age, or growth restricted, and those born following a pregnancy complicated by diabetes mellitus. The goal of this review is to discuss specific aspects of this new research. First, we focus on promising new data testing the role of buccal dextrose gel in the management of asymptomatic neonatal hypoglycemia. Second, we highlight some of the clinical implications of a large, prospective study documenting the association of specific glycemic patterns with neurodevelopmental outcomes at two years of age.

Indexed as

Continuous glucose monitoringDextrose gelInfant of a diabetic motherIntrauterine growth restrictionLarge for gestational ageLate pretermNeonatal hypoglycemiaSmall for gestational age

Identifiers

PMID27168942
PMCPMC4862061
OpenAlexW2346200292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.